Journal article
Proton pump inhibitors and diarrhoea related to Clostridium difficile infection in hospitalised patients: a case-control study
Internal Medicine Journal, Vol.42(5), pp.591-594
2012
Abstract
The incidence and disease severity of Clostridium difficile infection are rising. There is increasing evidence of a potential association between proton-pump inhibitors (PPI) and C. difficile infection. We performed a case–control study to examine the relationship between PPI and polymerase chain reaction (PCR)-proven C. difficile infection in 137 hospitalised patients in a tertiary hospital in Western Australia. Only antibiotic exposure within 3 months prior to onset of diarrhoea was associated with PCR-proven C. difficile infection (odds ratio 5.97, 95% confidence interval 2.40–14.8, P= 0.001). A restricted analysis on those who had exposure to antibiotics within 3 months before the onset of diarrhoea did not change the negative association between PPI exposure and PCR-proven C. difficile infection. Long-term PPI usage and intensity of PPI exposure prior to onset of diarrhoea were not significantly associated with C. difficile infection.
Details
- Title
- Proton pump inhibitors and diarrhoea related to Clostridium difficile infection in hospitalised patients: a case-control study
- Authors/Creators
- A.D. Leonard (Author/Creator) - Glenfield HospitalK.M. Ho (Author/Creator) - Royal Perth HospitalJ. Flexman (Author/Creator) - Royal Perth Hospital
- Publication Details
- Internal Medicine Journal, Vol.42(5), pp.591-594
- Publisher
- Wiley
- Identifiers
- 991005541271607891
- Copyright
- © 2012 Royal Australasian College of Physicians
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.120 Inflammatory Bowel Diseases & Infections
- 1.120.1133 Clostridium Infections
- Web Of Science research areas
- Medicine, General & Internal
- ESI research areas
- Clinical Medicine