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Published (Version of Record)CC BY V4.0, Open Access
Journal article
Pyrimidine biosynthetic enzyme CAD: Its function, regulation, and diagnostic potential
International Journal of Molecular Sciences, Vol.22(19), Article 10253
2021
Abstract
CAD (Carbamoyl-phosphate synthetase 2, Aspartate transcarbamoylase, and Dihydroorotase) is a multifunctional protein that participates in the initial three speed-limiting steps of pyrimidine nucleotide synthesis. Over the past two decades, extensive investigations have been conducted to unmask CAD as a central player for the synthesis of nucleic acids, active intermediates, and cell membranes. Meanwhile, the important role of CAD in various physiopathological processes has also been emphasized. Deregulation of CAD-related pathways or CAD mutations cause cancer, neurological disorders, and inherited metabolic diseases. Here, we review the structure, function, and regulation of CAD in mammalian physiology as well as human diseases, and provide insights into the potential to target CAD in future clinical applications.
Details
- Title
- Pyrimidine biosynthetic enzyme CAD: Its function, regulation, and diagnostic potential
- Authors/Creators
- G. Li (Author/Creator) - Hunan Normal UniversityD. Li (Author/Creator) - Zhengzhou UniversityT. Wang (Author/Creator) - Murdoch UniversityS. He (Author/Creator) - Hunan Normal University
- Publication Details
- International Journal of Molecular Sciences, Vol.22(19), Article 10253
- Publisher
- MDPI
- Identifiers
- 991005540190007891
- Copyright
- © 2021 by the authors
- Murdoch Affiliation
- Centre for Molecular Medicine and Innovative Therapeutics
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.197 Molecular & Cell Biology - Mitochondria
- 1.197.1797 Arginine Metabolism
- Web Of Science research areas
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- Chemistry, Multidisciplinary
- ESI research areas
- Chemistry