Journal article
Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum
Experimental Parasitology, Vol.119(2), pp.301-303
2008
Abstract
This study analysed the intracellular delivery capacity of insect derived pyrrhocoricin with a peptide cargo in Cryptosporidium parvum in vitro using fluorescence microscopy. Results revealed that pyrrhocoricin was capable of acting as a delivery vehicle in transducing peptides across the parasite cell membrane for multiple life-cycle stages. The successful transduction may aid in target validation and the delivery of future peptide-based drugs against this important human pathogen.
Details
- Title
- Pyrrhocoricin as a potential drug delivery vehicle for Cryptosporidium parvum
- Authors/Creators
- A. Boxell (Author/Creator)S.H.C. Lee (Author/Creator)R. Jefferies (Author/Creator)P. Watt (Author/Creator)R. Hopkins (Author/Creator)S. Reid (Author/Creator)A. Armson (Author/Creator)U. Ryan (Author/Creator)
- Publication Details
- Experimental Parasitology, Vol.119(2), pp.301-303
- Publisher
- Academic Press
- Identifiers
- 991005544400607891
- Copyright
- © 2008 Elsevier Inc.
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences; School of Nursing and Midwifery
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.246 Diarrheal Diseases
- 1.246.985 Cryptosporidium
- Web Of Science research areas
- Parasitology
- ESI research areas
- Microbiology