Files and links (1)
Open Access CC BY V4.0
Journal article
Quality of life implications for elevated trait impulsivity in people with Parkinson's disease
Quality of life research, Vol.32(4), pp.1143-1150
2023
PMID: 36637657
Abstract
Background
Several non-motor features of Parkinson’s disease (PD) are known to adversely affect patient health-related quality of life (HRQL). However, the specific impact of neuropsychiatric complications, such as impulsive behaviour, is yet to be elucidated.
Objectives
The present cross-sectional, observational study aimed to investigate the effects of heightened trait impulsivity on HRQL in individuals with PD.
Methods
A total of 322 people with idiopathic PD were sequentially recruited from Movement Disorder clinics across Australia. Trait impulsivity in patients was determined by Barratt’s Impulsiveness Scale Version 11 (BIS-11), and grouped into tertiles (low, medium, and high). Patient HRQL was determined by the 39-item Parkinson’s Disease Questionnaire (PDQ-39), complemented by the Cambridge Behavioural Inventory-Revised (CBI-R) indicating caregivers’ perception of patient HRQL.
Results
When total BIS-11 scores were grouped into tertiles, patient perceived and caregiver-perceived HRQL were 1.7-fold (p < .001) and 2.2-fold (p < .001) worse in the high BIS-11 group when compared to patients in the low group. Univariate analysis revealed significant associations between second-order attentional (p < .001) and non-planning (p < .001) impulsivity domains with PDQ-39 scores. When controlling for confounding demographic and clinical variables, a multivariate linear regression model revealed second-order attentional impulsivity was independently predictive of poor patient perceived HRQL (p < .001).
Conclusion
These findings suggest that increasing trait impulsivity is significantly associated with patient perceived HRQL in PD. Improved knowledge and recognition of subclinical impulsivity may guide clinicians’ treatment and reduce disease burden for patients experiencing PD symptoms.
Details
- Title
- Quality of life implications for elevated trait impulsivity in people with Parkinson's disease
- Authors/Creators
- Ashani Jeyadevan - The University of Notre Dame AustraliaMegan Bakeberg - The University of Western AustraliaMichelle Byrnes - The University of Western AustraliaJade Kenna - The University of Notre Dame AustraliaSarah McGregor - St Vincent's Hospital MelbourneSoumya Ghosh - The University of Western AustraliaMalcom K Horne - The University of MelbourneRick Stell - The University of Western AustraliaTess Evans - The University of Notre Dame AustraliaFrank L Mastaglia - Perron Institute for Neurological and Translational ScienceRyan Anderton - The University of Notre Dame Australia
- Publication Details
- Quality of life research, Vol.32(4), pp.1143-1150
- Publisher
- Springer Nature
- Identifiers
- 991005884843607891
- Copyright
- © The Author(s) 2023.
- Murdoch Affiliation
- Research and Innovation Office
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: SDGs in the Output
Metrics
1 Record Views