Journal article
Quantitative linkage genome scan for atopy in a large collection of Caucasian families
Human Genetics, Vol.121(1), pp.83-92
2007
Abstract
Quantitative phenotypes correlated with a complex disorder offer increased power to detect linkage in comparison to affected-unaffected classifications. Asthma is a complex disorder characterized by periods of bronchial obstruction and increased bronchial hyper reactivity. In childhood and early adulthood, asthma is frequently associated also with quantitative measures of atopy. Genome wide quantitative multipoint linkage analysis was conducted for serum IgE levels and percentage of positive skin prick test (SPT(per)) using three large groups of families originally ascertained for asthma. In this report, 438 and 429 asthma families were informative for linkage using IgE and SPT(per) which represents 690 independent families. Suggestive linkage (LOD > or = 2) was found on chromosomes 1, 3, and 8q with maximum LODs of 2.34 (IgE), 2.03 (SPT(per)), and 2.25 (IgE) near markers D1S1653, D3S2322-D3S1764, and D8S2324, respectively. The results from chromosomes 1 and 3 replicate previous reports of linkage. We also replicate linkage to 5q with peak LODs of 1.96 (SPT(per)) and 1.77 (IgE) at or near marker D5S1480. Our results provide further evidence implicating chromosomes 1, 3, and 5q. The current report represents one of the biggest genome scans so far reported for asthma related phenotypes. This study also demonstrates the utility of increased sample sizes and quantitative phenotypes in linkage analysis of complex disorders.
Details
- Title
- Quantitative linkage genome scan for atopy in a large collection of Caucasian families
- Authors/Creators
- B.T. Webb (Author/Creator) - Virginia Commonwealth UniversityE. Oord (Author/Creator)A. Akkari (Author/Creator) - Genetics Research, Glaxo SmithKline, 27709, USAS. Wilton (Author/Creator) - Australian Neuromuscular Research Institute, Experimental Molecular Medicine Group, Perth, AustraliaT. Ly (Author/Creator) - Australian Neuromuscular Research Institute, Experimental Molecular Medicine Group, Perth, AustraliaR. Duff (Author/Creator) - Australian Neuromuscular Research Institute, Experimental Molecular Medicine Group, Perth, AustraliaK.C. Barnes (Author/Creator) - Johns Hopkins UniversityK. Carlsen (Author/Creator) - Oslo University HospitalJ. Gerritsen (Author/Creator) - University Medical Center GroningenW. Lenney (Author/Creator) - Royal Stoke University HospitalM. Silverman (Author/Creator) - University of LeicesterP. Sly (Author/Creator) - The University of Western AustraliaJ. Sundy (Author/Creator) - Duke UniversityJ. Tsanakas (Author/Creator) - Hippocration General HospitalA. Berg (Author/Creator)M. Whyte (Author/Creator)M. Blumenthal (Author/Creator) - University of MinnesotaJ. Vestbo (Author/Creator) - Hvidovre HospitalL. Middleton (Author/Creator) - Genetics Research, Glaxo SmithKline, 27709, USAP.J. Helms (Author/Creator) - Royal Aberdeen Children's HospitalW.H. Anderson (Author/Creator) - Genetics Research, Glaxo SmithKline, 27709, USAS.G. Pillai (Author/Creator) - Genetics Research, Glaxo SmithKline, 27709, USA
- Publication Details
- Human Genetics, Vol.121(1), pp.83-92
- Publisher
- Springer Verlag
- Identifiers
- 991005541780607891
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Industry collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.65 Allergy
- 1.65.44 Asthma
- Web Of Science research areas
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics