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Journal article
RGTA® or ReGeneraTing Agents mimic heparan sulfate in regenerative medicine: from concept to curing patients
Glycoconjugate journal, Vol.34(3), pp.325-338
2017
PMCID: PMC5487810
PMID: 27924424
Abstract
The importance of extracellular matrix (ECM) integrity in maintaining normal tissue function is highlighted by numerous pathologies and situations of acute and chronic injury associated with dysregulation or destruction of ECM components. Heparan sulfate (HS) is a key component of the ECM, where it fulfils important functions associated with tissue homeostasis. Its degradation following tissue injury disrupts this delicate equilibrium and may impair the wound healing process. ReGeneraTing Agents (RGTA(A (R))s) are polysaccharides specifically designed to replace degraded HS in injured tissues. The unique properties of RGTA(A (R)) (resistance to degradation, binding and protection of ECM structural and signaling proteins, like HS) permit the reconstruction of the ECM, restoring both structural and biochemical functions to this essential substrate, and facilitating the processes of tissue repair and regeneration. Here, we review 25 years of research surrounding this HS mimic, supporting the mode of action, pre-clinical studies and therapeutic efficacy of RGTA(A (R)) in the clinic, and discuss the potential of RGTA(A (R)) in new branches of regenerative medicine.
Details
- Title
- RGTA® or ReGeneraTing Agents mimic heparan sulfate in regenerative medicine: from concept to curing patients
- Authors/Creators
- Denis Barritault - OTR3, 4 Rue Francaise, F-75001 Paris, FranceMarie Gilbert-Sirieix - OTR3, 4 Rue Francaise, F-75001 Paris, FranceKim L Rice - OTR3, 4 Rue Francaise, F-75001 Paris, FranceFernando Sineriz - OTR3, 4 Rue Francaise, F-75001 Paris, FranceDulce Papy-Garcia - Univ Paris Est, Univ Paris Est Creteil, UPEC ERL CNRS 4397 9215, Lab Cell Growth & Tissue Repair CRRET, F-94000 Creteil, FranceChristophe Baudouin - Inst Vis, 17 Rue Moreau, F-75012 Paris, FrancePascal Desgranges - Univ Paris Est Creteil, Hop Henri Mondor, Dept Vasc Surg, 51 Ave Marechal de Lattre de Tassigny, F-94000 Creteil, FranceGilbert Zakine - Serv Chirurg Plast & Reconstructrice, 33 Rue Tour, F-75016 Paris, FranceJean-Louis Saffar - Univ Paris 05, Sorbonne Paris Cite, Fac Chirurg Dent, Lab Pathol Imagerie & Biotherapies Orofaciales EA, 1 Rue Maurice Arnoux, F-92120 Montrouge, FranceJohan van Neck - Erasmus MC Univ, Med Ctr, Dept Plast & Reconstruct Surg, Rotterdam, Netherlands
- Publication Details
- Glycoconjugate journal, Vol.34(3), pp.325-338
- Publisher
- Springer Nature
- Identifiers
- 991005634570207891
- Copyright
- © The Author(s) 2016.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.132 Extracellular Matrix & Cell Differentiation
- 1.132.816 Glycosaminoglycans
- Web Of Science research areas
- Biochemistry & Molecular Biology
- ESI research areas
- Biology & Biochemistry