Journal article
Randomized, blinded, placebo-controlled clinical trial of N-acetylcysteine in dogs with spinal cord trauma from acute intervertebral disc disease
Spine (Philadelphia, Pa. 1976), Vol.33(13), pp.1397-1402
2008
PMID: 18520934
Abstract
Study Design
The effect of N-acetylcysteine administration intravenously before hemilaminectomy surgery on neurologic outcome and 15F2t isoprostane excretion in dogs was examined in a blinded, placebo-controlled trial.
Objective
To determine the effect of N-acetylcysteine administration on urinary 15F2t isoprostane excretion and neurologic outcome following hemilaminectomy for intervertebral disc disease.
Summary of Background Data
Oxidative stress is a mediator of secondary injury to the spinal cord following trauma. Acute intervertebral disc disease is associated with increased oxidative damage in dogs. N-acetylcysteine has preserved neurologic function following experimental spinal cord injury.
Methods
Seventy dogs with naturally occurring acute intervertebral disc disease were administered either with saline placebo or N-acetylcysteine intravenously before hemilaminectomy surgery. Serial neurologic examinations were performed before and 1, 2, 7, 14, and 42 days following treatment. Urinary excretion of 15F2t isoprostane excretion was determined before treatment and 1 hour after surgery.
Results
Analysis of subjective data did not reveal any significant effect of N-acetylcysteine on neurologic outcome or rate of improvement of neurologic score in the 42 days following treatment. Urinary 15F2t isoprostane excretion was not significantly different between treatment groups (P > 0.05).
Conclusion.
N-acetylcysteine intravenously before hemilaminectomy has no effect on urinary 15F2t isoprostane excretion or neurologic outcome. Treatment of dogs with the antioxidant N-acetylcysteine before hemilaminectomy, while not detrimental, does not affect neurologic outcome in the 42 days following surgery.
Details
- Title
- Randomized, blinded, placebo-controlled clinical trial of N-acetylcysteine in dogs with spinal cord trauma from acute intervertebral disc disease
- Authors/Creators
- Wendy I. Baltzer - Oregon State UniversityMaureen A. McMichael - Texas A&M Univ, Coll Vet Med, Dept Small Anim Med & Surg, College Stn, TX 77843 USAGiselle L. Hosgood - Louisiana State Univ, Sch Vet Med, Dept Vet Clin Sci, Baton Rouge, LA 70803 USASharon C. Kerwin - Texas A&M Univ, Coll Vet Med, Dept Small Anim Med & Surg, College Stn, TX 77843 USAJonathan M. Levine - Texas A&M Univ, Coll Vet Med, Dept Small Anim Med & Surg, College Stn, TX 77843 USAJorg M. Steiner - Texas A&M Univ, Coll Vet Med, Dept Small Anim Med & Surg, College Stn, TX 77843 USACraig G. Ruaux - Oregon State University
- Publication Details
- Spine (Philadelphia, Pa. 1976), Vol.33(13), pp.1397-1402
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Identifiers
- 991005592765307891
- Copyright
- © 2008 Lippincott Williams
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.82 Gait & Posture
- 1.82.875 Spinal Cord Injury
- Web Of Science research areas
- Clinical Neurology
- Orthopedics
- ESI research areas
- Neuroscience & Behavior