Journal article
Rates of age‐ and amyloid β‐associated cortical atrophy in older adults with superior memory performance
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol.11(1), pp.566-575
2019
Abstract
Introduction
Superior cognitive performance in older adults may reflect underlying resistance to age‐associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Aβ‐associated neurodegeneration.
Methods
Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Aβ status.
Results
Of the case‐matched SuperAgers and cognitively normal for age older adults, 40.7% and 40.1%, respectively, were Aβ+. Rates of age‐ and Aβ‐associated atrophy did not differ between the groups on any measure. Aβ− individuals displayed the slowest rates of atrophy.
Discussion
Maintenance of superior memory in late life does not reflect resistance to age‐ or Aβ‐associated atrophy. However, those individuals who reached old age without cognitive impairment nor elevated Aβ deposition (i.e. Aβ−) displayed reduced rates of cortical atrophy.
Details
- Title
- Rates of age‐ and amyloid β‐associated cortical atrophy in older adults with superior memory performance
- Authors/Creators
- C. Dang (Author/Creator) - The University of MelbourneN. Yassi (Author/Creator) - Florey Institute of Neuroscience and Mental HealthK.D. Harrington (Author/Creator) - Florey Institute of Neuroscience and Mental HealthY. Xia (Author/Creator) - Biosecurity AustraliaY.Y. Lim (Author/Creator) - Florey Institute of Neuroscience and Mental HealthD. Ames (Author/Creator) - The University of MelbourneS.M. Laws (Author/Creator) - Edith Cowan UniversityM. Hickey (Author/Creator) - The University of MelbourneS. Rainey‐Smith (Author/Creator)H.R. Sohrabi (Author/Creator) - Edith Cowan UniversityJ.D. Doecke (Author/Creator) - Biosecurity AustraliaJ. Fripp (Author/Creator) - Biosecurity AustraliaO. Salvado (Author/Creator) - Biosecurity AustraliaP.J. Snyder (Author/Creator) - University of Rhode IslandM. Weinborn (Author/Creator) - Edith Cowan UniversityV.L. Villemagne (Author/Creator) - Florey Institute of Neuroscience and Mental HealthC.C. Rowe (Author/Creator) - Austin HealthC.L. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental HealthP. Maruff (Author/Creator) - Florey Institute of Neuroscience and Mental HealthB. Chambers (Author/Creator)E. Chiu (Author/Creator)R. Clarnette (Author/Creator)D. Darby (Author/Creator)M. Davison (Author/Creator)J. Drago (Author/Creator)P. Drysdale (Author/Creator)J. Gilbert (Author/Creator)K. Lim (Author/Creator)N. Lautenschlager (Author/Creator)D. LoGiudice (Author/Creator)P. McCardle (Author/Creator)S. McFarlane (Author/Creator)A. Mander (Author/Creator)J. Merory (Author/Creator)D. O'Connor (Author/Creator)R. Scholes (Author/Creator)M. Samuel (Author/Creator)D. Trivedi (Author/Creator)M. Woodward (Author/Creator)
- Publication Details
- Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol.11(1), pp.566-575
- Publisher
- Elsevier Inc. on behalf of the Alzheimer’s Association
- Identifiers
- 991005542935007891
- Copyright
- © 2019 The Authors
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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