Rationale and protocol for the 7-and 8-year longitudinal assessments of eye health in a cohort of young adults in the Raine Study

Samantha Sze-Yee Lee; Gareth Lingham; Seyhan Yazar; Paul G. Sanfilippo; Jason Charng; Fred K. Chen; Alex W. Hewitt; Fletcher Ng; Christopher Hammond; Leon M. Straker; Peter R. Eastwood; Stuart MacGregor; Kathryn A. Rose; Robyn M. Lucas; Jeremy A. Guggenheim; Seang-Mei Saw; Minas T. Coroneo; Mingguang He; David A. Mackey

doi:10.1136/bmjopen-2019-033440

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Rationale and protocol for the 7-and 8-year longitudinal assessments of eye health in a cohort of young adults in the Raine Study

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Rationale and protocol for the 7-and 8-year longitudinal assessments of eye health in a cohort of young adults in the Raine Study

Samantha Sze-Yee Lee, Gareth Lingham, Seyhan Yazar, Paul G. Sanfilippo, Jason Charng, Fred K. Chen, Alex W. Hewitt, Fletcher Ng, Christopher Hammond, Leon M. Straker, …

BMJ open, Vol.10(3), e033440

2020

DOI: https://doi.org/10.1136/bmjopen-2019-033440

PMCID: PMC7170556

PMID: 32217560

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Abstract

Raine Study

cohort study

myopia

ocular measures

young adults

Introduction: Eye diseases and visual impairment more commonly affect elderly adults, thus, the majority of ophthalmic cohort studies have focused on older adults. Cohort studies on the ocular health of younger adults, on the other hand, have been few. The Raine Study is a longitudinal study that has been following a cohort since their birth in 1989–1991. As part of the 20-year follow-up of the Raine Study, participants underwent a comprehensive eye examination. As part of the 27- and 28-year follow-ups, eye assessments are being conducted and the data collected will be compared with those of the 20-year follow-up. This will provide an estimate of population incidence and updated prevalence of ocular conditions such as myopia and keratoconus, as well as longitudinal change in ocular parameters in young Australian adults. Additionally, the data will allow exploration of the environmental, health and genetic factors underlying inter-subject differential long-term ocular changes. Methods and analysis: Participants are being contacted via telephone, email and/or social media and invited to participate in the eye examination. At the 27-year follow-up, participants completed a follow-up eye screening, which assessed visual acuity, autorefraction, ocular biometry and ocular sun exposure. Currently, at the 28-year follow-up, a comprehensive eye examination is being conducted which, in addition to all the eye tests performed at the 27-year follow-up visit, includes tonometry, optical coherence tomography, funduscopy and anterior segment topography, among others. Outcome measures include the incidence of refractive error and pterygium, an updated prevalence of these conditions, and the 8-year change in ocular parameters. Ethics and dissemination: The Raine Study is registered in the Australian New Zealand Clinical Trials Registry. The Gen2 20-year, 27-year and 28-year follow-ups are approved by the Human Research Ethics Committee of the University of Western Australia. Findings resulting from the study will be published in health or medical journals and presented at conferences.

Details

Title: Rationale and protocol for the 7-and 8-year longitudinal assessments of eye health in a cohort of young adults in the Raine Study
Authors/Creators: Samantha Sze-Yee Lee - The University of Western Australia
Gareth Lingham - Lions Eye Institute
Seyhan Yazar - Garvan Institute of Medical Research
Paul G. Sanfilippo - Centre for Eye Research Australia
Jason Charng - The University of Western Australia
Fred K. Chen - The University of Western Australia
Alex W. Hewitt - University of Tasmania
Fletcher Ng - Lions Eye Institute
Christopher Hammond - King's College London
Leon M. Straker - Curtin University
Peter R. Eastwood - The University of Western Australia
Stuart MacGregor - QIMR Berghofer Medical Research Institute
Kathryn A. Rose - The University of Sydney
Robyn M. Lucas - Australian National University
Jeremy A. Guggenheim - Cardiff University
Seang-Mei Saw - National University of Singapore
Minas T. Coroneo - UNSW Sydney
Mingguang He - Sun Yat-sen University
David A. Mackey - The University of Western Australia
Publication Details: BMJ open, Vol.10(3), e033440
Publisher: Bmj Publishing Group
Number of pages: 10
Grant note: Telethon Institute for Child Health Research, Australia University of Notre Dame, Australia University of Western Australia, Australia Women's and Infant's Research Foundation, Australia Edith Cowan University, Australia 1 021 105 / National Health and Medical Research Council (NHMRC), Australia; National Health and Medical Research Council (NHMRC) of Australia 1 121 979; 1 126 494 / NHMRC, Australia; National Health and Medical Research Council (NHMRC) of Australia Curtin University, Australia Raine Medical Research Foundation, Australia Murdoch University, Australia NHMRC; National Health and Medical Research Council (NHMRC) of Australia
Identifiers: 991005592649407891
Murdoch Affiliation: Vice Chancellery
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.36 Ophthalmology; 1.36.813 Vision Disorders
Web Of Science research areas: Ophthalmology
ESI research areas: Clinical Medicine