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Reactive glial cells in CNS demyelination contain both GC and GFAP
Journal article   Peer reviewed

Reactive glial cells in CNS demyelination contain both GC and GFAP

W.M. Carroll, A.R. Jennings and F.L. Mastaglia
Brain Research, Vol.411(2), pp.364-369
1987
DOI: https://doi.org/10.1016/0006-8993(87)91088-2
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Abstract

The glial cell response to anti-galactocerebroside (GC) induced demyelination of the cat optic nerve was studied using electron microscopy and immunocytochemistry. Oligodendrocytes, which are a primary target for anti-GC, were depleted in the early lesions but astrocytes survived and showed reactive changes. Astrocytic processes exhibited dual staining for both GC and glialfibrillary acidic protein, a feature not seen in astrocytes outside the lesion or in normal optic nerve. These reactive astrocytes did not stain for anti-myelin basic protein, nor did they contain myelin debris, making it unlikely that the GC immunoreactivity was due to phagocytosis of myelin. Rather, it is postulated that the presence of GC in these cells represents a process of dedifferentiation to a more primitive state in which both astrocytic and oligodendrocytic determinants are synthesized, and that these reactive glial cells may be precursors of a new population of remyelinating oligodendrocytes.

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Source: InCites

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Collaboration types
Domestic collaboration
Citation topics
1 Clinical & Life Sciences
1.203 Neuromuscular Disorders
1.203.1430 Oligodendrocyte Myelination
Web Of Science research areas
Neurosciences
ESI research areas
Neuroscience & Behavior
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