Journal article
Reactivity to heparin in patients with alpha-gal allergy
Annals of Allergy, Asthma & Immunology, Vol.129(4), pp.515-517
2022
Abstract
Galactose-alpha-1,3-galactose (alpha-gal) syndrome is an immunoglobulin (Ig)E-mediated allergy syndrome to an oligosaccharide found in nonprimate mammalian meat and mammalian-derived products. 1 Oral consumption reactions are characteristically delayed, but are immediate with parenteral administration. 1 Since the discovery of alpha-gal IgE antibodies while investigating hypersensitivity reactions to cetuximab, much attention has been paid to both theoretical risks and reported cases of hypersensitivity reactions to various medications and medical devices derived from nonprimate mammals. 1 ,2 The true extent of this risk is still largely unknown. 3 One medication of interest is heparin; both unfractionated heparin and low-molecular weight heparin, enoxaparin, are derived from porcine intestinal tissue. In a case of immediate hypersensitivity to heparin in a patient with a high concentration of alpha-gal–specific IgE (sIgE), we would like to draw attention to positive skin testing result to heparin products.
Details
- Title
- Reactivity to heparin in patients with alpha-gal allergy
- Authors/Creators
- G. Koo (Author/Creator)J. Plager (Author/Creator)J.M. Fahrenholz (Author/Creator)E. Phillips (Author/Creator)C. Stone (Author/Creator)
- Publication Details
- Annals of Allergy, Asthma & Immunology, Vol.129(4), pp.515-517
- Publisher
- Elsevier Inc.
- Identifiers
- 991005545184607891
- Copyright
- © 2022 American College of Allergy, Asthma & Immunology.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.65 Allergy
- 1.65.264 Allergy Mechanisms
- Web Of Science research areas
- Allergy
- Immunology
- ESI research areas
- Immunology