Journal article
Recent advances in oligonucleotide therapeutics in oncology
International Journal of Molecular Sciences, Vol.22(7), Article 3295
2021
Abstract
Cancer is one of the leading causes of death worldwide. Conventional therapies, including surgery, radiation, and chemotherapy have achieved increased survival rates for many types of cancer over the past decades. However, cancer recurrence and/or metastasis to distant organs remain major challenges, resulting in a large, unmet clinical need. Oligonucleotide therapeutics, which include antisense oligonucleotides, small interfering RNAs, and aptamers, show promising clinical outcomes for disease indications such as Duchenne muscular dystrophy, familial amyloid neuropathies, and macular degeneration. While no approved oligonucleotide drug currently exists for any type of cancer, results obtained in preclinical studies and clinical trials are encouraging. Here, we provide an overview of recent developments in the field of oligonucleotide therapeutics in oncology, review current clinical trials, and discuss associated challenges.
Details
- Title
- Recent advances in oligonucleotide therapeutics in oncology
- Authors/Creators
- H. Xiong (Author/Creator)R.N. Veedu (Author/Creator)S.D. Diermeier (Author/Creator)
- Publication Details
- International Journal of Molecular Sciences, Vol.22(7), Article 3295
- Publisher
- MDPI
- Identifiers
- 991005545026907891
- Copyright
- © 2021 by the authors
- Murdoch Affiliation
- Centre for Molecular Medicine and Innovative Therapeutics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 2 Chemistry
- 2.170 Nucleic Acids Chemistry
- 2.170.988 Oligonucleotide Modifications
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary
- ESI research areas
- Chemistry