Journal article
Recent advances in the understanding of severe cutaneous adverse reactions
British Journal of Dermatology, Vol.177(5), pp.1234-1247
2017
Abstract
Severe cutaneous adverse reactions (SCARs) encompass a heterogeneous group of delayed hypersensitivity reactions, which are most frequently caused by drugs. Our understanding of several aspects of SCAR syndromes has evolved considerably over the previous decade. This review explores evolving knowledge on the immunopathogenic mechanisms, pharmacogenomic associations, in-vivo and ex-vivo diagnostics for causality assessment and medication cross-reactivity data related to SCAR syndromes. Given the rarity and severity of these diseases, multidisciplinary collaboration through large international, national and/or multicentre networks to collect prospective data on patients with SCAR syndromes should be prioritized. This will further enhance a systematised framework for translating epidemiological, clinical, and immunopathogenetic advances into preventive efforts and improved outcomes for patients.
Details
- Title
- Recent advances in the understanding of severe cutaneous adverse reactions
- Authors/Creators
- N.R. Adler (Author/Creator)A.K. Aung (Author/Creator)E.N. Ergen (Author/Creator)J. Trubiano (Author/Creator)M.S.Y. Goh (Author/Creator)E.J. Phillips (Author/Creator)
- Publication Details
- British Journal of Dermatology, Vol.177(5), pp.1234-1247
- Publisher
- Wiley
- Identifiers
- 991005544094507891
- Copyright
- © 2017 British Association of Dermatologists
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.265 Dermatology - Skin Allergies
- 1.265.1140 Drug Hypersensitivity
- Web Of Science research areas
- Dermatology
- ESI research areas
- Clinical Medicine