Journal article
Receptor Co‑targeting Strategies for Personalized Ovarian Cancer Therapy
International journal of nanomedicine, Vol.21, 633450
2026
PMID: 42732377
Abstract
Ovarian cancer remains highly lethal due to late diagnosis, frequent recurrence, and rapid development of resistance to platinum-based chemotherapy. Although rational drug combinations targeting multiple oncogenic pathways hold promise, their clinical utility is often compromised by dose-limiting toxicity and tumor heterogeneity. Antibody-drug conjugates (ADCs) offer an alternative by delivering potent agents directly to tumor cells, thereby reducing systemic toxicity. This approach could be further enhanced by the dual targeting of co-expressed tumor-specific cell surface receptor pairs to broaden tumor coverage and enable the precise delivery of synergistically active drugs. Furthermore, nanotechnology-based carriers extend these concepts by enabling the integration of multiple targeting ligands and payloads into a single drug-delivery platform. Systematic identification and validation of novel co-targeting cell surface receptors, such as G protein-coupled receptors (GPCRs), characterized by high tumor relevance and rapid internalization, may improve tumor coverage and drug uptake in therapy-resistant subpopulations. The outlined strategies are very promising to advance precise and personalized treatment strategies for ovarian cancer. However, dual-receptor approaches remain largely investigational, with limited preclinical validation, and their clinical translation is challenged by receptor heterogeneity, uncertain tumor selectivity, potential off-target effects, and inefficient delivery due to tumor-microenvironment barriers. Furthermore, manufacturing, safety, and regulatory requirements need to be addressed.
Details
- Title
- Receptor Co‑targeting Strategies for Personalized Ovarian Cancer Therapy
- Authors/Creators
- Weranga Rajapaksha - The University of AdelaidePreethi Eldi - The University of AdelaideTodd A Gillam - Murdoch UniversityAnton Blencowe - The University of AdelaideSanjay Garg - The University of AdelaideHugo Albrecht - The University of AdelaideRiya Khetan - The University of Adelaide
- Publication Details
- International journal of nanomedicine, Vol.21, 633450
- Publisher
- DOVE MEDICAL PRESS LTD
- Number of pages
- 16
- Identifiers
- 991005917858607891
- Copyright
- © 2026 Rajapaksha et al.
- Murdoch Affiliation
- School of Mathematics, Statistics, Chemistry and Physics
- Language
- English
- Resource Type
- Journal article
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