Journal article
Recombination mapping of the susceptibility region for sporadic inclusion body myositis within the major histocompatibility complex
Journal of Neuroimmunology, Vol.235(1-2), pp.77-83
2011
Abstract
Susceptibility to sporadic inclusion body myositis (sIBM) in Caucasians has been consistently associated with alleles of the major histocompatibility complex (MHC) 8.1 ancestral haplotype (AH) (defined by HLA-B*0801 and HLA-DRB1*0301). In this study recombination mapping was utilised to further refine the known 8.1AH susceptibility region near HLA-DRB1*0301. Caucasian sIBM patients carrying part of the 8.1AH were genotyped for a selection of 8.1AH-haplotypic polymorphisms. A common 8.1AH-specific susceptibility region was defined, spanning 172 kb and encompassing three genes — HLA-DRB3, HLA-DRA and BTNL2. It is thus likely that 8.1AH-derived susceptibility to sIBM originates from at least one of these genes.
Details
- Title
- Recombination mapping of the susceptibility region for sporadic inclusion body myositis within the major histocompatibility complex
- Authors/Creators
- A.P. Scott (Author/Creator)N.G. Laing (Author/Creator)F. Mastaglia (Author/Creator)M. Needham (Author/Creator)M.C. Walter (Author/Creator)M.C. Dalakas (Author/Creator)R.J.N. Allcock (Author/Creator)
- Publication Details
- Journal of Neuroimmunology, Vol.235(1-2), pp.77-83
- Publisher
- Elsevier
- Identifiers
- 991005542474507891
- Copyright
- © 2011 Published by Elsevier B.V.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.1684 Dermatomyositis
- Web Of Science research areas
- Immunology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior