Recovery of CD4+ T Cells in HIV Patients With a Stable Virologic Response to Antiretroviral Therapy Is Associated With Polymorphisms of Interleukin-6 and Central Major Histocompatibility Complex Genes

S. Fernandez; A.A. Rosenow; I.R. James; S.G. Roberts; R.C. Nolan; M.A. French; P. Price

doi:10.1097/01.qai.0000188990.57760.e3

Back

Recovery of CD4+ T Cells in HIV Patients With a Stable Virologic Response to Antiretroviral Therapy Is Associated With Polymorphisms of Interleukin-6 and Central Major Histocompatibility Complex Genes

Journal article

Peer reviewed

Recovery of CD4+ T Cells in HIV Patients With a Stable Virologic Response to Antiretroviral Therapy Is Associated With Polymorphisms of Interleukin-6 and Central Major Histocompatibility Complex Genes

S. Fernandez, A.A. Rosenow, I.R. James, S.G. Roberts, R.C. Nolan, M.A. French and P. Price

JAIDS Journal of Acquired Immune Deficiency Syndromes, Vol.41(1), pp.1-5

01/2006

DOI: https://doi.org/10.1097/01.qai.0000188990.57760.e3

Files and links (1)

url

Link to Published Version *Subscription may be requiredView

Abstract

We investigated whether polymorphisms in genes associated with HIV disease progression and/or immune activation affect CD4 + T-cell recovery in HIV patients who began combination antiretroviral therapy (ART) with advanced immunodeficiency and achieved stable control of plasma viremia. Patients with CD4 + T-cell counts <300 cells/μL (n = 33) and >400 cells/μL (n = 37) on ART were compared. A multiple case-control logistic regression associated carriage of BAT1(1,2) or interleukin (IL)6-174(2,2) with low CD4 + T-cell counts (P = 0.012). BAT1*2 uniquely marks the central major histocompatibility complex region of a conserved haplotype (HLA-A1,B8,BAT1*2,TNFA-308*2,DR3,DQ2). There was no association between alleles carried at CCR5Δ32, CCR5 59029, CCR5 59353, CCR2+190 (V64I), SDF1 3′UTR, IL1A+4845, IL1B+3953, IL4-589, IL10-592, IL10-R1+536, IL10-R1+1112, IL12B 3′UTR, TNFA-308, or TNFA-1031 and CD4 + T-cell counts. We suggest that immune activation and/or CD4 + T-cell apoptosis in HIV patients on effective ART is influenced by genetic factors.

Details

Title: Recovery of CD4+ T Cells in HIV Patients With a Stable Virologic Response to Antiretroviral Therapy Is Associated With Polymorphisms of Interleukin-6 and Central Major Histocompatibility Complex Genes
Authors/Creators: S. Fernandez (Author/Creator)
A.A. Rosenow (Author/Creator)
I.R. James (Author/Creator)
S.G. Roberts (Author/Creator)
R.C. Nolan (Author/Creator)
M.A. French (Author/Creator)
P. Price (Author/Creator)
Publication Details: JAIDS Journal of Acquired Immune Deficiency Syndromes, Vol.41(1), pp.1-5
Publisher: Lippincott Williams & Wilkins
Identifiers: 991005540959907891
Copyright: © 2005 by Lippincott Williams & Wilkins.
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

28 Record Views

23 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV Pathogenesis
Web Of Science research areas: Immunology; Infectious Diseases
ESI research areas: Immunology