Journal article
Reduced protein synthesis in spinal anterior horn neurons in wobbler mouse mutant
Experimental Neurology, Vol.67(2), pp.423-432
1980
Abstract
We studied protein synthesis in cervical anterior horn neurons in the “wobbler” mouse by measuring l-[4,5-3H]leucine incorporation using a light microscopic autoradiographic technique. Cytoplasmic incorporation of the isotope was significantly reduced not only in vacuolated nerve cells but also in those which were microscopically normal suggesting that impaired protein synthetic activity precedes the earliest morphologic changes seen with the light microscope. Isotope incorporation was reduced in small as well as large neurons suggesting that the disease process is not confined to α-motoneurons.
Details
- Title
- Reduced protein synthesis in spinal anterior horn neurons in wobbler mouse mutant
- Authors/Creators
- K. Murakami (Author/Creator)F.L. Mastaglia (Author/Creator)W.G. Bradley (Author/Creator)
- Publication Details
- Experimental Neurology, Vol.67(2), pp.423-432
- Publisher
- Elsevier
- Identifiers
- 991005543971307891
- Copyright
- © 1980 Published by Elsevier Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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