Journal article
Regeneration and repair in the healing lung
Clinical & Translational Immunology, Vol.9(7)
2020
Abstract
The lung achieves an efficient gas exchange between a complex non‐sterile atmosphere and the body via a delicate and extensive epithelial surface, with high efficiency because of elastic deformation allowing for an increase and decrease in volume during the process of breathing and because of an extensive vasculature which aids rapid gas diffusion. The lungs’ large surface area exposes the organ to a continual risk of damage from pathogens, toxins or irritants; however, lung damage can be rapidly healed via regenerative processes that restore its structure and function. In response to sustained and extensive damage, the lung is healed via a non‐regenerative process resulting in scar tissue which locally stiffens its structure, which over time leads to a serious loss of lung function and to increasing morbidities. This review discusses what is known about the factors which influence whether a lung is healed by regeneration or repair and what potential new therapeutic approaches may positively influence lung healing.
Details
- Title
- Regeneration and repair in the healing lung
- Authors/Creators
- A. Lucas (Author/Creator) - The University of Western AustraliaJ. Yasa (Author/Creator) - The University of Western AustraliaM. Lucas (Author/Creator) - The University of Western Australia
- Publication Details
- Clinical & Translational Immunology, Vol.9(7)
- Publisher
- John Wiley and Sons Inc. on behalf of Australian and New Zealand Society for Immunology Inc.
- Identifiers
- 991005543767007891
- Copyright
- © 2020 The Authors
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
44 File views/ downloads
98 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Citation topics
- 1 Clinical & Life Sciences
- 1.154 Assisted Ventilation
- 1.154.1057 Pulmonary Surfactant
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology