Journal article
Regional ventilation distribution and dead space in anaesthetized horses treated with and without continuous positive airway pressure: novel insights by electrical impedance tomography and volumetric capnography
Veterinary Anaesthesia and Analgesia, Vol.45(1), pp.31-40
2018
Abstract
Objective: The aim of this study was to evaluate the effect of continuous positive airway pressure (CPAP) on regional distribution of ventilation and dead space in anaesthetized horses.
Study design: Randomized, experimental, crossover study.
Animals: A total of eight healthy adult horses.
Methods: Horses were anaesthetized twice with isoflurane in 50% oxygen and medetomidine as continuous infusion in dorsal recumbency, and administered in random order either CPAP (8 cmH2O) or NO CPAP for 3 hours. Electrical impedance tomography (and volumetric capnography (VCap) measurements were performed every 30 minutes. Lung regions with little ventilation [dependent silent spaces (DSSs) and nondependent silent spaces (NSSs)], centre of ventilation (CoV) and dead space variables, as well as venous admixture were calculated. Statistical analysis was performed using multivariate analysis of variance and Pearson correlation.
Results: Data from six horses were statistically analysed. In CPAP, the CoV shifted to dependent parts of the lungs (p < 0.001) and DSSs were significantly smaller (p < 0.001), while no difference was seen in NSSs. Venous admixture was significantly correlated with DSS with the treatment time taken as covariate (p < 0.0001; r = 0.65). No differences were found for any VCap parameters.
Conclusions and clinical relevance: In dorsally recumbent anaesthetized horses, CPAP of 8 cmH2O results in redistribution of ventilation towards the dependent lung regions, thereby improving ventilation-perfusion matching. This improvement was not associated with an increase in dead space indicative for a lack in distension of the airways or impairment of alveolar perfusion.
Details
- Title
- Regional ventilation distribution and dead space in anaesthetized horses treated with and without continuous positive airway pressure: novel insights by electrical impedance tomography and volumetric capnography
- Authors/Creators
- M. Mosing (Author/Creator) - Murdoch UniversityU. Auer (Author/Creator) - University of ViennaP. MacFarlane (Author/Creator) - University of BristolD. Bardell (Author/Creator) - University of LiverpoolJ.P. Schramel (Author/Creator) - University of ViennaS.H. Böhm (Author/Creator) - Swisstom (Switzerland)R. Bettschart-Wolfensberger (Author/Creator) - University of ZurichA.D. Waldmann (Author/Creator) - Swisstom (Switzerland)
- Publication Details
- Veterinary Anaesthesia and Analgesia, Vol.45(1), pp.31-40
- Publisher
- Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia
- Identifiers
- 991005541295007891
- Copyright
- © 2017 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- 1 Clinical & Life Sciences
- 1.154 Assisted Ventilation
- 1.154.277 Mechanical Ventilation
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science