Regression of canine oral papillomas is associated with infiltration of CD4+ and CD8+ lymphocytes

P.K. Nicholls; P.F. Moore; D.M. Anderson; R.A. Moore; N.R. Parry; G.W. Gough; M.A. Stanley

doi:10.1006/viro.2000.0789

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Regression of canine oral papillomas is associated with infiltration of CD4+ and CD8+ lymphocytes

Journal article

Open access

Peer reviewed

Regression of canine oral papillomas is associated with infiltration of CD4+ and CD8+ lymphocytes

P.K. Nicholls, P.F. Moore, D.M. Anderson, R.A. Moore, N.R. Parry, G.W. Gough and M.A. Stanley

Virology, Vol.283(1), pp.31-39

2001

DOI: https://doi.org/10.1006/viro.2000.0789

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Abstract

Canine oral papillomavirus (COPV) infection is used in vaccine development against mucosal papillomaviruses. The predictable, spontaneous regression of the papillomas makes this an attractive system for analysis of cellular immunity. Immunohistochemical analysis of the timing and phenotype of immune cell infiltration revealed a marked influx of leukocytes during wart regression, including abundant CD4+ and CD8+ cells, with CD4+ cells being most numerous. Comparison of these findings, and those of immunohistochemistry using TCRαβ-, TCRγδ-, CD1a-, CD1c-, CD11a-, CD11b-, CD11c-, CD18-, CD21-, and CD49d-specific monoclonal antibodies, with previously published work in the human, ox, and rabbit models revealed important differences between these systems. Unlike bovine papillomavirus lesions, those of COPV do not have a significant gamma/delta T-cell infiltrate. Furthermore, COPV lesions had numerous CD4+ cells, unlike cottontail rabbit papillomavirus lesions. The lymphocyte infiltrate in the dog resembled that in human papillomavirus lesions, indicating that COPV is an appropriate model for human papillomavirus immunity.

Details

Title: Regression of canine oral papillomas is associated with infiltration of CD4+ and CD8+ lymphocytes
Authors/Creators: P.K. Nicholls (Author/Creator) - University of Cambridge
P.F. Moore (Author/Creator) - University of California, Davis
D.M. Anderson (Author/Creator) - University of Cambridge
R.A. Moore (Author/Creator) - University of Cambridge
N.R. Parry (Author/Creator) - The Hertz Corporation
G.W. Gough (Author/Creator) - The Hertz Corporation
M.A. Stanley (Author/Creator) - University of Cambridge
Publication Details: Virology, Vol.283(1), pp.31-39
Publisher: Academic Press
Identifiers: 991005543434507891
Copyright: 2001 Academic Press.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.179 Oncology; 1.179.108 HPV and Cervical Cancer
Web Of Science research areas: Virology
ESI research areas: Microbiology