Journal article
Regulation of MicroRNAs, and the Correlations of MicroRNAs and Their Targeted Genes by Zinc Oxide Nanoparticles in Ovarian Granulosa Cells
PLoS ONE, Vol.11(5), Art. e0155865
2016
Abstract
Zinc oxide (ZnO) nanoparticles (NPs) have been applied in numerous industrial products and personal care products like sunscreens and cosmetics. The released ZnO NPs from consumer and household products into the environment might pose potential health issues for animals and humans. In this study the expression of microRNAs and the correlations of microRNAs and their targeted genes in ZnO NPs treated chicken ovarian granulosa cells were investigated. ZnSO4 was used as the sole Zn2+ provider to differentiate the effects of NPs from Zn2+. It was found that ZnO-NP-5 μg/ml specifically regulated the expression of microRNAs involved in embryonic development although ZnO-NP-5 μg/ml and ZnSO4-10 μg/ml treatments produced the same intracellular Zn concentrations and resulted in similar cell growth inhibition. And ZnO-NP-5 μg/ml also specifically regulated the correlations of microRNAs and their targeted genes. This is the first investigation that intact NPs in ZnO-NP-5 μg/ml treatment specifically regulated the expression of microRNAs, and the correlations of microRNAs and their targeted genes compared to that by Zn2+. This expands our knowledge for biological effects of ZnO NPs and at the same time it raises the health concerns that ZnO NPs might adversely affect our biological systems, even the reproductive systems through regulation of specific signaling pathways.
Details
- Title
- Regulation of MicroRNAs, and the Correlations of MicroRNAs and Their Targeted Genes by Zinc Oxide Nanoparticles in Ovarian Granulosa Cells
- Authors/Creators
- Y.K. Mishra (Author/Creator)Y. Zhao (Author/Creator) - Qingdao Agricultural UniversityL. Li (Author/Creator) - Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao, 266109, P. R. China.L-J Min (Author/Creator) - Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao, 266109, P. R. China.L-Q Zhu (Author/Creator) - Qingdao Agricultural UniversityQ-Y Sun (Author/Creator) - State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, P. R. ChinaH. Zhang (Author/Creator) - State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.X-Q Liu (Author/Creator) - Qingdao Agricultural UniversityW-D Zhang (Author/Creator) - Qingdao Agricultural UniversityW. Ge (Author/Creator) - Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao, 266109, P. R. China.J-J Wang (Author/Creator) - Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao, 266109, P. R. China.J-C Liu (Author/Creator) - Key Laboratory of Animal Reproduction and Germplasm Enhancement in Universities of Shandong, Qingdao, 266109, P. R. China.Z-H Hao (Author/Creator) - Qingdao Agricultural University
- Publication Details
- PLoS ONE, Vol.11(5), Art. e0155865
- Publisher
- Public Library of Science
- Identifiers
- 991005543782507891
- Copyright
- © 2016 Zhao et al.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 2 Chemistry
- 2.67 Nanoparticles
- 2.67.231 Nanotoxicology
- Web Of Science research areas
- Nanoscience & Nanotechnology
- ESI research areas
- Multidisciplinary