Journal article
Regulation of T helper cell differentiation by respiratory tract dendritic cells
Immunology and Cell Biology, Vol.77(5), pp.428-433
1999
Abstract
Studies on dendritic cells (DC) of the respiratory and gastric mucosae have identified an extensive network of cells that represent the predominant antigen-presenting cell type at these sites. Under steady-state conditions, respiratory tract DC (RTDC) are specialized for antigen uptake and spontaneously migrate to local lymph nodes, although in vivo transfer studies have shown that the T-cell priming activity of these cells is restricted to low-level, Th2-skewed responses. Following exposure to inflammatory stimuli, the migration of RTDC to lymph nodes is accelerated and is associated with a rapid and dramatic increase in the ability of these cells to induce both Th1- and Th2-dependent immunity. Under normal circumstances, however, responsiveness of epithelial RTDC to maturation stimuli is regulated by locally produced micro-environmental factors, including pro-inflammatory cytokines, reactive oxygen species and prostanoids. These studies have led to a greater understanding of airway DC function and their role in T helper cell differentiation and provide the basis for future studies to determine the role of the cells in the aetiology and pathogenesis of respiratory immunoinflammatory disorders.
Details
- Title
- Regulation of T helper cell differentiation by respiratory tract dendritic cells
- Authors/Creators
- P.A. Stumbles (Author/Creator)
- Publication Details
- Immunology and Cell Biology, Vol.77(5), pp.428-433
- Publisher
- Nature Publishing Group
- Identifiers
- 991005543264607891
- Copyright
- 1999 Nature Publishing Group
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.358 Dendritic Cell Therapy
- Web Of Science research areas
- Cell Biology
- Immunology
- ESI research areas
- Immunology