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Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease
Journal article   Open access   Peer reviewed

Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease

Ajish Ariyath, Zoe Mputhia, Christopher Dougherty, Bushra Kaleelur Rahuman, W M A D Binosha Fernando, Belinda Brown, Samantha L Gardener, Stephanie R Rainey-Smith, Ralph Martins and Prashant Bharadwaj
Alzheimer's & dementia, Vol.22(2), e71191
2026
PMID: 41724666
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Published2.07 MBDownloadView
CC BY V4.0 Open Access

Abstract

Alzheimer Disease - physiopathology Animals Autophagy - physiology Diet Exercise - physiology Humans Sleep - physiology
Alzheimer's disease (AD) is a progressive, age-related, neurodegenerative disorder marked by cognitive decline, memory loss, and accumulation of amyloid beta (Aβ) plaques and tau tangles. A key feature of AD is impaired protein homeostasis, often driven by autophagy dysfunction. Autophagy, a cellular degradation and recycling process, plays a vital role in maintaining neuronal health and is increasingly recognized as a therapeutic target in AD. Lifestyle factors such as diet, physical activity, and sleep can positively influence autophagy and support cognitive function. Intermittent fasting (IF) and calorie restriction (CR) activate autophagy and promote longevity; physical activity enhances cerebral blood flow and neurotrophic signaling; and adequate sleep supports autophagic processes, while sleep deprivation disrupts them. However, excessive autophagy may be detrimental. Understanding how lifestyle modulates autophagy is essential for developing non-pharmacological strategies to delay or prevent AD. This review explores the mechanistic links between autophagy and lifestyle interventions to support brain health in aging.

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UN Sustainable Development Goals (SDGs)

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