Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease

Ajish Ariyath; Zoe Mputhia; Christopher Dougherty; Bushra Kaleelur Rahuman; W M A D Binosha Fernando; Belinda Brown; Samantha L Gardener; Stephanie R Rainey-Smith; Ralph Martins; Prashant Bharadwaj

doi:10.1002/alz.71191

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Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease

Journal article

Open access

Peer reviewed

Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease

Ajish Ariyath, Zoe Mputhia, Christopher Dougherty, Bushra Kaleelur Rahuman, W M A D Binosha Fernando, Belinda Brown, Samantha L Gardener, Stephanie R Rainey-Smith, Ralph Martins and Prashant Bharadwaj

Alzheimer's & dementia, Vol.22(2), e71191

2026

DOI: https://doi.org/10.1002/alz.71191

PMID: 41724666

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Abstract

Alzheimer Disease - physiopathology

Animals

Autophagy - physiology

Diet

Exercise - physiology

Humans

Sleep - physiology

Alzheimer's disease (AD) is a progressive, age-related, neurodegenerative disorder marked by cognitive decline, memory loss, and accumulation of amyloid beta (Aβ) plaques and tau tangles. A key feature of AD is impaired protein homeostasis, often driven by autophagy dysfunction. Autophagy, a cellular degradation and recycling process, plays a vital role in maintaining neuronal health and is increasingly recognized as a therapeutic target in AD. Lifestyle factors such as diet, physical activity, and sleep can positively influence autophagy and support cognitive function. Intermittent fasting (IF) and calorie restriction (CR) activate autophagy and promote longevity; physical activity enhances cerebral blood flow and neurotrophic signaling; and adequate sleep supports autophagic processes, while sleep deprivation disrupts them. However, excessive autophagy may be detrimental. Understanding how lifestyle modulates autophagy is essential for developing non-pharmacological strategies to delay or prevent AD. This review explores the mechanistic links between autophagy and lifestyle interventions to support brain health in aging.

Details

Title: Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease
Authors/Creators: Ajish Ariyath - Edith Cowan University
Zoe Mputhia - Edith Cowan University
Christopher Dougherty - Edith Cowan University
Bushra Kaleelur Rahuman - Edith Cowan University
W M A D Binosha Fernando - Edith Cowan University
Belinda Brown - Murdoch University, Centre for Healthy Ageing
Samantha L Gardener - Edith Cowan University
Stephanie R Rainey-Smith - Murdoch University, Centre for Healthy Ageing
Ralph Martins - Edith Cowan University
Prashant Bharadwaj - Edith Cowan University
Publication Details: Alzheimer's & dementia, Vol.22(2), e71191
Publisher: Wiley Periodicals LLC on behalf of Alzheimer's Association.; HOBOKEN
Number of pages: 29
Grant note: National Foundation for Medical Research and Innovation National Health and Medical Research Council APP1107109 / Australian Research Council Dementia Research Development Fellowship (MRC-ARC)
Identifiers: 991005866791907891
Murdoch Affiliation: Research and Innovation Office; Centre for Healthy Ageing
Language: English
Resource Type: Journal article

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