Journal article
Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements
Cellular and Molecular Life Sciences, Vol.69(21), pp.3613-3634
2012
Abstract
There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as "junk DNA", it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5' and 3' untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This review discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.
Details
- Title
- Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements
- Authors/Creators
- L.W. Barrett (Author/Creator) - The University of Western AustraliaS. Fletcher (Author/Creator) - The University of Western AustraliaS.D. Wilton (Author/Creator) - The University of Western Australia
- Publication Details
- Cellular and Molecular Life Sciences, Vol.69(21), pp.3613-3634
- Publisher
- Birkhauser Verlag Basel
- Identifiers
- 991005540258607891
- Copyright
- 2012 The Authors
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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