Regulation of the frontocortical sodium pump by Na+ in Alzheimer's disease: Difference from the age-matched control but similarity to the rat model

C. Kairane; K. Roots; T. Uusma; N. Bogdanovic; E. Karelson; S. Kõks; M. Zilmer

doi:10.1016/S0014-5793(02)03510-X

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Regulation of the frontocortical sodium pump by Na+ in Alzheimer's disease: Difference from the age-matched control but similarity to the rat model

Journal article

Peer reviewed

Regulation of the frontocortical sodium pump by Na+ in Alzheimer's disease: Difference from the age-matched control but similarity to the rat model

C. Kairane, K. Roots, T. Uusma, N. Bogdanovic, E. Karelson, S. Kõks and M. Zilmer

FEBS Letters, Vol.531(2), pp.241-244

2002

DOI: https://doi.org/10.1016/S0014-5793(02)03510-X

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Abstract

The Na+ and K+ dependence of the frontocortical Na,K‐ATPase in Alzheimer's disease (AD) was compared with that in human control (Co) and rat AD model. In AD, the relationship between the Na/K ratio and the Na,K‐ATPase activity showed noticeable left‐shift with three‐fold increase in the enzyme affinity for Na+ (K 0.5=10 and 30 mM in AD and Co, respectively). The Na+ dependence of the enzyme in AD showed two different Hill coefficients (n H), 1.1 and 0.3, whereas the Co value of n H was higher (1.4). The rat AD model generated by ibotenic acid revealed a Na+ dependence similar to AD. The K+ dependence of the Na,K‐ATPase showed no significant difference in AD and Co. Compared with Co, AD produced a shift in the break of the Na,K‐ATPase Arrhenius plot, suggesting remarkable alterations in the enzyme lipid environment. Our findings support the hypothesis that dysfunction of the Na,K‐ATPase in AD is provoked by altered Na+ dependence of the enzyme. An impairment of the pump functionality might serve as an early mechanism of AD that should be interrupted by selective pharmacological agents.

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Title: Regulation of the frontocortical sodium pump by Na+ in Alzheimer's disease: Difference from the age-matched control but similarity to the rat model
Authors/Creators: C. Kairane (Author/Creator) - University of Tartu
K. Roots (Author/Creator) - University of Tartu
T. Uusma (Author/Creator) - University of Tartu
N. Bogdanovic (Author/Creator) - Karolinska Institutet
E. Karelson (Author/Creator) - University of Tartu
S. Kõks (Author/Creator) - University of Tartu
M. Zilmer (Author/Creator) - University of Tartu
Publication Details: FEBS Letters, Vol.531(2), pp.241-244
Publisher: Elsevier
Identifiers: 991005541304507891
Copyright: © 2015 Federation of European Biochemical Societies
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.79 Molecular & Cell Biology - Physiology; 1.79.874 Cardiac Glycosides
Web Of Science research areas: Biochemistry & Molecular Biology; Biophysics; Cell Biology
ESI research areas: Biology & Biochemistry