Relapse Patterns in NMOSD: Evidence for Earlier Occurrence of Optic Neuritis and Possible Seasonal Variation

Elham Khalilidehkordi; Laura Clarke; Simon Arnett; Wajih Bukhari; Sofia Jimenez Sanchez; Cullen O'Gorman; Jing Sun; Kerri M Prain; Mark Woodhall; Roger Silvestrini; Christine S Bundell; David Abernethy; Sandeep Bhuta; Stefan Blum; Mike Boggild; Karyn Boundy; Bruce J Brew; Matthew Brown; Wallace Brownlee; Helmut Butzkueven; William M Carroll; Celia Chen; Alan Coulthard; Russell C Dale; Chandi Das; Marzena J Fabis-Pedrini; David Fulcher; David Gillis; Simon Hawke; Robert Heard; Andrew PD Henderson; Saman Heshmat; Suzanne Hodgkinson; Trevor J Kilpatrick; John King; Chris Kneebone; Andrew J Kornberg; Jeannette Lechner-Scott; Ming-Wei Lin; Christopher Lynch; Richard AL Macdonell; Deborah F Mason; Pamela A McCombe; Jennifer Pereira; John D Pollard; Sudarshini Ramanathan; Stephen W Reddel; Cameron Shaw; Judith Spies; James Stankovich; Ian Sutton; Steve Vucic; Michael Walsh; Richard C Wong; Eppie M Yiu; Michael H Barnett; Allan G Kermode; Mark P Marriott; John Parratt; Mark Slee; Bruce V Taylor; Ernest Willoughby; Fabienne Brilot; Angela Vincent; Patrick Waters; Simon A Broadley

doi:10.3389/fneur.2020.00537

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Relapse Patterns in NMOSD: Evidence for Earlier Occurrence of Optic Neuritis and Possible Seasonal Variation

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Relapse Patterns in NMOSD: Evidence for Earlier Occurrence of Optic Neuritis and Possible Seasonal Variation

Elham Khalilidehkordi, Laura Clarke, Simon Arnett, Wajih Bukhari, Sofia Jimenez Sanchez, Cullen O'Gorman, Jing Sun, Kerri M Prain, Mark Woodhall, Roger Silvestrini, …

Frontiers in Neurology, Vol.11, 537

2020

DOI: https://doi.org/10.3389/fneur.2020.00537

PMCID: PMC7308484

PMID: 32612571

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Abstract

Clinical sciences

Neurosciences

Psychology

Neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) show overlap in their clinical features. We performed an analysis of relapses with the aim of determining differences between the two conditions. Cases of NMOSD and age- and sex-matched MS controls were collected from across Australia and New Zealand. Demographic and clinical information, including relapse histories, were recorded using a standard questionnaire. There were 75 cases of NMOSD and 101 MS controls. There were 328 relapses in the NMOSD cases and 375 in MS controls. Spinal cord and optic neuritis attacks were the most common relapses in both NMOSD and MS. Optic neuritis (p < 0.001) and area postrema relapses (P = 0.002) were more common in NMOSD and other brainstem attacks were more common in MS (p < 0.001). Prior to age 30 years, attacks of optic neuritis were more common in NMOSD than transverse myelitis. After 30 this pattern was reversed. Relapses in NMOSD were more likely to be treated with acute immunotherapies and were less likely to recover completely. Analysis by month of relapse in NMOSD showed a trend toward reduced risk of relapse in February to April compared to a peak in November to January (P = 0.065). Optic neuritis and transverse myelitis are the most common types of relapse in NMOSD and MS. Optic neuritis tends to occur more frequently in NMOSD prior to the age of 30, with transverse myelitis being more common thereafter. Relapses in NMOSD were more severe. A seasonal bias for relapses in spring-summer may exist in NMOSD.

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Title: Relapse Patterns in NMOSD: Evidence for Earlier Occurrence of Optic Neuritis and Possible Seasonal Variation
Authors/Creators: Elham Khalilidehkordi - Griffith University
Laura Clarke - Griffith University
Simon Arnett - Griffith University
Wajih Bukhari - Griffith University
Sofia Jimenez Sanchez
Cullen O'Gorman
Jing Sun - Griffith University
Kerri M Prain - Queensland Health
Mark Woodhall - John Radcliffe Hospital
Roger Silvestrini - Westmead Hospital
Christine S Bundell - The University of Western Australia
David Abernethy - Wellington Hospital
Sandeep Bhuta - Griffith University
Stefan Blum - Princess Alexandra Hospital
Mike Boggild - Townsville Hospital
Karyn Boundy - Royal Adelaide Hospital
Bruce J Brew - UNSW Sydney
Matthew Brown - Translational Research Institute
Wallace Brownlee - Auckland City Hospital
Helmut Butzkueven - Monash University
William M Carroll - Perron Institute for Neurological and Translational Science
Celia Chen - Flinders Medical Centre
Alan Coulthard - Royal Brisbane and Women's Hospital
Russell C Dale - Westmead Hospital
Chandi Das - Canberra Hospital
Marzena J Fabis-Pedrini - Perron Institute for Neurological and Translational Science
David Fulcher - Royal Prince Alfred Hospital
David Gillis - Queensland Health
Simon Hawke - The University of Sydney
Robert Heard - Westmead Hospital
Andrew PD Henderson - Westmead Hospital
Saman Heshmat - Griffith University
Suzanne Hodgkinson - Liverpool Hospital
Trevor J Kilpatrick - Florey Institute of Neuroscience and Mental Health
John King - The Royal Melbourne Hospital
Chris Kneebone - Royal Adelaide Hospital
Andrew J Kornberg - Royal Children's Hospital
Jeannette Lechner-Scott
Ming-Wei Lin - Royal Prince Alfred Hospital
Christopher Lynch - University of Auckland
Richard AL Macdonell - Austin Health
Deborah F Mason - Christchurch Hospital
Pamela A McCombe - Royal Brisbane and Women's Hospital
Jennifer Pereira - University of Auckland
John D Pollard - Westmead Hospital
Sudarshini Ramanathan - Children's Hospital at Westmead
Stephen W Reddel - The University of Sydney
Cameron Shaw - Deakin University
Judith Spies - Royal Prince Alfred Hospital
James Stankovich
Ian Sutton - St Vincent's Hospital Sydney
Steve Vucic - Westmead Hospital
Michael Walsh - Princess Alexandra Hospital
Richard C Wong - Queensland Health
Eppie M Yiu - Royal Children's Hospital
Michael H Barnett - The University of Sydney
Allan G Kermode - Perron Institute for Neurological and Translational Science
Mark P Marriott - The Royal Melbourne Hospital
John Parratt - Royal Prince Alfred Hospital
Mark Slee - Flinders Medical Centre
Bruce V Taylor - University of Tasmania
Ernest Willoughby - Auckland City Hospital
Fabienne Brilot - Children's Hospital at Westmead
Angela Vincent - John Radcliffe Hospital
Patrick Waters - John Radcliffe Hospital
Simon A Broadley - Griffith University
Publication Details: Frontiers in Neurology, Vol.11, 537
Publisher: Frontiers Media S.A.
Identifiers: 991005624464107891
Copyright: © 2020 Khalilidehkordi, Clarke, Arnett, Bukhari, Jimenez Sanchez, O'Gorman, Sun, Prain, Woodhall, Silvestrini, Bundell, Abernethy, Bhuta, Blum, Boggild, Boundy, Brew, Brown, Brownlee, Butzkueven, Carroll, Chen, Coulthard, Dale, Das, Fabis-Pedrini, Fulcher, Gillis, Hawke, Heard, Henderson, Heshmat, Hodgkinson, Kilpatrick, King, Kneebone, Kornberg, Lechner-Scott, Lin, Lynch, Macdonell, Mason, McCombe, Pereira, Pollard, Ramanathan, Reddel, Shaw, Spies, Stankovich, Sutton, Vucic, Walsh, Wong, Yiu, Barnett, Kermode, Marriott, Parratt, Slee, Taylor, Willoughby, Brilot, Vincent, Waters and Broadley.
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.203 Neuromuscular Disorders; 1.203.147 Multiple Sclerosis
Web Of Science research areas: Clinical Neurology; Neurosciences
ESI research areas: Clinical Medicine