Journal article
Relation of exploratory behavior of rats in elevated plus-maze to brain receptor binding properties and serum growth hormone levels
European Neuropsychopharmacology, Vol.7(4), pp.289-294
1997
Abstract
Forty-five male Wistar rats were selected according to their behavior in the elevated plus-maze. They were separated as follows: animals with low exploratory activity (`anxious'), an `intermediate' group and animals having high exploratory activity (`non-anxious'). Various receptor binding studies and hormonal assays were also performed in these selected rats. The affinity of 5-hydroxytryptamine 5-HT2A receptors in the frontal cortex was lower in the `anxious' rats compared to home-cage controls and `non-anxious' animals. Moreover, the number of cholecystokinin (CCK) receptors in the hippocampus was significantly elevated in the `anxious' group compared to home-cage control animals. The blood levels of growth hormone (GH) were significantly lower in the `non-anxious' rats compared to `anxious' counterparts. In conclusion, it seems likely that the decreased exploratory activity of rats is related to the increased 5-hydroxytryptamine (5-HT) and CCK mediated neurotransmission in the brain. The different serum levels of GH in the selected rats probably reflect alterations in the activity of 5-HT and CCK.
Details
- Title
- Relation of exploratory behavior of rats in elevated plus-maze to brain receptor binding properties and serum growth hormone levels
- Authors/Creators
- S. Kõks (Author/Creator)E. Vasar (Author/Creator)A. Soosaar (Author/Creator)A. Lang (Author/Creator)V. Volke (Author/Creator)V. Võikar (Author/Creator)M. Bourin (Author/Creator)P.T. Männistö (Author/Creator)
- Publication Details
- European Neuropsychopharmacology, Vol.7(4), pp.289-294
- Publisher
- Elsevier
- Identifiers
- 991005541454207891
- Copyright
- © 1997 Elsevier Science B.V.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.195 Neuroendocrine & Intestinal Disorders
- 1.195.1096 Gastrin/CCK Functions
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- Pharmacology & Pharmacy
- Psychiatry
- ESI research areas
- Neuroscience & Behavior