Journal article
Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease
Alzheimer's & Dementia, Vol.14(11), pp.1427-1437
2018
Abstract
Introduction
Little is known about effects of physical activity (PA) in genetically driven early‐onset autosomal dominant Alzheimer's disease (AD).
Methods
A total of 372 individuals participating at the Dominantly Inherited Alzheimer Network study were examined to evaluate the cross‐sectional relationship of PA with cognitive performance, functional status, cognitive decline, and AD biomarkers in cerebrospinal fluid. Mutation carriers were categorized as high or low exercisers according to WHO recommendations.
Results
Mutation carriers with high PA showed significantly better cognitive and functional performance and significantly less AD‐like pathology in cerebrospinal fluid than individuals with low PA. Mutation carriers with high PA scored 3.4 points better on Mini Mental State Examination at expected symptom onset and fulfilled the diagnosis of very mild dementia 15.1 years later compared with low exercisers.
Discussion
These results support a beneficial effect of PA on cognition and AD pathology even in individuals with genetically driven autosomal dominant AD.
Details
- Title
- Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease
- Authors/Creators
- S. Müller (Author/Creator) - Hertie Institute for Clinical Brain ResearchO. Preische (Author/Creator) - German Center for Neurodegenerative DiseasesH.R. Sohrabi (Author/Creator) - Edith Cowan UniversityS. Gräber (Author/Creator) - German Center for Neurodegenerative DiseasesM. Jucker (Author/Creator) - German Center for Neurodegenerative DiseasesJ.M. Ringman (Author/Creator) - Memory and Aging Center, Keck School of Medicine of USC, Los Angeles, CA, USA.R.N. Martins (Author/Creator) - Edith Cowan UniversityE. McDade (Author/Creator) - University of PittsburghP.R. Schofield (Author/Creator) - Neuroscience Research AustraliaB. Ghetti (Author/Creator) - Indiana University – Purdue University IndianapolisM. Rossor (Author/Creator) - UCL Institute of NeurologyN.N. Fox (Author/Creator) - UCL Institute of NeurologyN.R. Graff-Radford (Author/Creator) - Jacksonville CollegeJ. Levin (Author/Creator) - German Center for Neurodegenerative DiseasesA. Danek (Author/Creator) - Ludwig-Maximilians-Universität MünchenJ. Vöglein (Author/Creator) - Ludwig-Maximilians-Universität MünchenS. Salloway (Author/Creator) - Brown UniversityC. Xiong (Author/Creator) - Washington University in St. LouisT. Benzinger (Author/Creator)V. Buckles (Author/Creator) - Washington University in St. LouisC.L. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental HealthR. Sperling (Author/Creator) - Brigham and Women's HospitalR.J. Bateman (Author/Creator) - Washington University in St. LouisJ.C. Morris (Author/Creator) - Washington University in St. LouisC. Laske (Author/Creator) - Hertie Institute for Clinical Brain Research
- Publication Details
- Alzheimer's & Dementia, Vol.14(11), pp.1427-1437
- Publisher
- Elsevier Inc.
- Identifiers
- 991005545274307891
- Copyright
- © 2018 The Alzheimer's Association
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Clinical Neurology
- ESI research areas
- Neuroscience & Behavior