Relationship between rate of infection and markers of inflammation/immunity in Holy Birman cats with feline coronavirus

S. Paltrinieri; G. Rossi; A. Giordano

doi:10.1016/j.rvsc.2014.08.009

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Relationship between rate of infection and markers of inflammation/immunity in Holy Birman cats with feline coronavirus

Journal article

Peer reviewed

Relationship between rate of infection and markers of inflammation/immunity in Holy Birman cats with feline coronavirus

S. Paltrinieri, G. Rossi and A. Giordano

Research in Veterinary Science, Vol.97(2), pp.263-270

2014

DOI: https://doi.org/10.1016/j.rvsc.2014.08.009

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Abstract

The aim of this study was to assess whether Holy Birman cats (HB) have a peculiar immune profile and a higher rate of infection by feline coronaviruses (FCoV). Leucocyte and lymphocyte subsets, antibody titers, α1-acid glycoprotein (AGP), globulin fractions, IL-4, IL-12 and IFN-γ in blood and fecal FCoV excretion were determined in HB (n = 75) and in cats from other breeds (n = 94). Significantly higher CD4/CD8 ratio, IFN-γ concentration and IL12/IL4 ratio and significantly lower IL-4 concentration and proportion of shedders were found in HB than in other breeds. No other differences were found. In conclusion, this study did not provide evidence of peculiar immune profiles in HB, except for a prevalent Th1 profile, that may explain why in our caseload the rate of shedders was lower in HB than in other breeds.

Details

Title: Relationship between rate of infection and markers of inflammation/immunity in Holy Birman cats with feline coronavirus
Authors/Creators: S. Paltrinieri (Author/Creator) - University of Milan
G. Rossi (Author/Creator) - University of Milan
A. Giordano (Author/Creator) - University of Milan
Publication Details: Research in Veterinary Science, Vol.97(2), pp.263-270
Publisher: Elsevier
Identifiers: 991005543988407891
Copyright: © 2014 Elsevier Ltd.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.104 Virology - General; 1.104.1788 Parvovirus Infections
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science