Files and links (1)
Open Access CC BY-NC-ND V4.0
Journal article
Renin-Angiotensin-Aldosterone System Profiling in Horses Before and After Exercise
Journal of veterinary internal medicine, Vol.39(2), e70036
2025
PMID: 40048547
Abstract
Background: The impact of exercise on the classical and alternative renin-angiotensin-aldosterone system (RAAS) pathways has not been studied in horses. Hypothesis: We hypothesized that exercise would activate both RAAS pathways and that endurance exercise would cause more activation of the classical pathway compared to short-duration, high-intensity exercise in horses. Animals: Twenty-five horses (21 client-owned and 4 research) were included in 4 exercise groups (10 Arabians, 50-mile ride [A-E]; 4 thoroughbreds, 1-mile treadmill exercise [TB-TM]; 5 thoroughbreds, 1–1/16th-mile race [TB-R]; and 6 quarter horses 330-500-yard race [QH-R]). Methods: Blood was collected before and after exercise. Equilibrium analysis was performed to measure serum RAAS metabo-lites and enzyme activities. The components of the RAAS pathways were compared before and after exercise. Post/pre-exercise ratios for each variable were compared among exercise groups. Data were reported as median (first, third quartiles; pre vs. post) and p < 0.05 was considered significant. Results: Exercise increased classical RAAS metabolites (pmol/L; angiotensin I, 2.5 [2.5, 2.5] vs. 8.2 [2.5, 19.0]; angiotensin II, 10.2 [6.0, 21.9] vs. 53.0 [37.4, 95.8]; aldosterone, 83.8 [53.4, 149.5] vs. 170.6 [112.2, 251.7]); alternative RAAS metabolites (pmol/L; angiotensin 1–7, 1.5 [1.5, 1.5] vs. 5.1 [1.5, 12.5]; angiotensin 1–5, 2.5 [2.5, 7.3] vs. 14.9 [9.0, 25.4]) and angiotensin-converting enzyme -2 activity (ng/mL; 16.6 [13.9, 20.4] vs. 25.2 [20.2, 33.0]; p < 0.001) for all horses. Angiotensin 1–7 ratios were higher for TB-R compared with TB-TM and A-E (p < 0.001). Conclusions and Clinical Importance: Both classical and alternative RAAS pathways increase after exercise in horses.
Details
- Title
- Renin-Angiotensin-Aldosterone System Profiling in Horses Before and After Exercise
- Authors/Creators
- Todd Holbrook - University of FloridaJorge Hernandez - University of FloridaTaralyn McCarrel - University of FloridaGuy Lester - University of FloridaMargaret Sleeper - University of FloridaOliver Domenig - Ludwig Boltzmann Institute Applied DiagnosticsDarcy Adin - University of Florida
- Publication Details
- Journal of veterinary internal medicine, Vol.39(2), e70036
- Publisher
- Wiley Periodicals LLC
- Grant note
- Oklahoma State University (http://data.elsevier.com/vocabulary/SciValFunders/100007069) College of Veterinary Medicine, University of Minnesota (http://data.elsevier.com/vocabulary/SciValFunders/100011523) AWD06761 / Racing Animal Medical Research Florida Department of Business and Professional Regulation
- Identifiers
- 991005884841207891
- Copyright
- © 2025 The Author(s).
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: SDGs in the Output
Metrics
1 Record Views