Research and standardization in Alzheimer's trials: Reaching international consensus

M.C. Carrillo; C.C. Rowe; C. Szoeke; C.L. Masters; D. Ames; T. O'Meara; S.L. Macaulay; A. Milner; K.A. Ellis; P. Maruff; S.R. Rainey-Smith; R.N. Martins; L.J. Bain; R.J. Head

doi:10.1016/j.jalz.2012.10.006

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Research and standardization in Alzheimer's trials: Reaching international consensus

Journal article

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Research and standardization in Alzheimer's trials: Reaching international consensus

M.C. Carrillo, C.C. Rowe, C. Szoeke, C.L. Masters, D. Ames, T. O'Meara, S.L. Macaulay, A. Milner, K.A. Ellis, P. Maruff, …

Alzheimer's & Dementi, Vol.9(2), pp.160-168

2012

DOI: https://doi.org/10.1016/j.jalz.2012.10.006

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Abstract

Alzheimer's disease (AD) is an epidemic facing the entire world. Increased knowledge gained during the past 25 years indicates that AD falls along a clinical and neuropathological spectrum represented as a continuum that extends from preclinical disease in which there are no symptoms, through early symptomatic phases, and finally to AD dementia. The Alzheimer's research community recognizes that imaging, body fluids, and cognitive biomarkers contribute to enhanced diagnostic confidence for AD. There has also been emerging consensus regarding the use of AD biomarkers in clinical trials. The use of biomarkers in clinical trials and practice is hampered by the lack of standardization. In response to the emerging need for standardization, an international meeting of AD researchers was held in Melbourne, Australia, in March 2012 to bring together key researchers, clinicians, industry, and regulatory stakeholders with the aim of generating consensus on standardization and validation of cognitive, imaging, and fluid biomarkers, as well as lifestyle parameters used in research centers worldwide.

Details

Title: Research and standardization in Alzheimer's trials: Reaching international consensus
Authors/Creators: M.C. Carrillo (Author/Creator) - Alzheimer's Association
C.C. Rowe (Author/Creator) - Austin Health
C. Szoeke (Author/Creator) - National Ageing Research Institute
C.L. Masters (Author/Creator) - Mental Health Research Institute
D. Ames (Author/Creator) - The University of Melbourne
T. O'Meara (Author/Creator) - Preventative Health
S.L. Macaulay (Author/Creator) - Preventative Health
A. Milner (Author/Creator) - Neurosciences Victoria, Carlton South, Victoria 3053, Australia
K.A. Ellis (Author/Creator) - The University of Melbourne
P. Maruff (Author/Creator) - Mental Health Research Institute
S.R. Rainey-Smith (Author/Creator)
R.N. Martins (Author/Creator) - Edith Cowan University
L.J. Bain (Author/Creator) - Independent Science Writer, Elverson PA, USA
R.J. Head (Author/Creator) - Preventative Health
Publication Details: Alzheimer's & Dementi, Vol.9(2), pp.160-168
Publisher: Wiley
Identifiers: 991005542752707891
Copyright: © 2013 The Alzheimer's Association
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.60 Dementia
Web Of Science research areas: Clinical Neurology
ESI research areas: Neuroscience & Behavior