Journal article
Restoration of CD4 T-cell responses to cytomegalovirus is short-lived in severely immunodeficient HIV-infected patients responding to highly active antiretroviral therapy
HIV Medicine, Vol.5(6), pp.407-414
2004
Abstract
Objectives. To define the level of pathogen-specific immune reconstitution persisting over 3 to 5 years of highly active antiretroviral therapy (HAART) in HIV-infected patients who began therapy with CD4 T-cell counts below 50 cells/μL. Methods. Cytomegalovirus (CMV)-specific T-cell responses were analysed in adult HIV-1-infected patients with nadir CD4 T-cell counts below 50 cells/μL before HAART. CMV-specific CD4 T-cell responses were measured by interferon-γ enzyme-linked immunospot assay (ELISpot assay), lymphoproliferation and interferon-γ levels in cell culture supernatants. Results. CD4 T-cell responses to CMV were low in untreated patients and remained low during the first year on HAART, but increased progressively to levels similar to those found in HIV-seronegative CMV-seropositive controls at 3 years. Responses then declined markedly and at 5 years were lower than controls. This could not be explained by changes in CD4 or CD8 T-cell counts or plasma HIV RNA levels. Interferon-γ and interleukin-5 responses to a mitogen were maintained or elevated. Conclusions. CMV-specific CD4 T-cell responses were found to decline after 3-5 years on HAART and may provide inadequate long-term protection against CMV disease in patients who are severely immunodeficient prior to treatment.
Details
- Title
- Restoration of CD4 T-cell responses to cytomegalovirus is short-lived in severely immunodeficient HIV-infected patients responding to highly active antiretroviral therapy
- Authors/Creators
- N.M. Keane (Author/Creator)P. Price (Author/Creator)S. Lee (Author/Creator)C.A. Almeida (Author/Creator)S.F. Stone (Author/Creator)I. James (Author/Creator)M.A. French (Author/Creator)
- Publication Details
- HIV Medicine, Vol.5(6), pp.407-414
- Publisher
- Blackwell Publishing
- Identifiers
- 991005541318407891
- Copyright
- © 2004 British HIV Association
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.161 Virology - Identification & Sequencing
- 1.161.711 Cytomegalovirus Infections
- Web Of Science research areas
- Infectious Diseases
- ESI research areas
- Immunology