Journal article
Restored platelet function after romiplostim treatment in a patient with immune thrombocytopenic purpura
British Journal of Haematology, Vol.149(4), pp.625-628
2010
Abstract
Whilst the precipitating aetiology of immune thrombocytopenic purpura (ITP) remains unclear, the predominant cause of the thrombocytopenia is the presence of circulating antiplatelet autoantibodies that coat platelets, leading to platelet destruction and clearance, primarily in the spleen. Traditional clinical management of patients with ITP, including treatment with corticosteroids, intravenous immunoglobulins, splenectomy, rituximab, and cyclophosphamide, aims to curb platelet destruction (Nurden et al, 2009a). Newer reagents approved for trial to treat ITP patients, such as thrombopoietin mimetics, romiplostim (Kuter et al, 2008) and eltrombopag, act primarily in the bone marrow to stimulate thrombopoiesis. Whilst neither plasma thrombopoietin levels nor platelet production kinetics are markedly altered in ITP patients, ITP anti-platelet autoantibodies interfere with megakaryocyte proliferation and platelet production in vitro (Chang et al, 2003). Here we describe a significant improvement to the nature and function of platelet immunoreceptor tyrosinebased activation motif (ITAM) receptors in an ITP patient with an autoantibody to platelet glycoprotein (GP)VI receiving romiplostim.
Details
- Title
- Restored platelet function after romiplostim treatment in a patient with immune thrombocytopenic purpura
- Authors/Creators
- E.E. Gardiner (Author/Creator)J.Y. Thom (Author/Creator)M. Al-Tamimi (Author/Creator)A. Hughes (Author/Creator)M.C. Berndt (Author/Creator)R.K. Andrews (Author/Creator)R.I. Baker (Author/Creator)
- Publication Details
- British Journal of Haematology, Vol.149(4), pp.625-628
- Publisher
- Blackwell Publishing Inc.
- Identifiers
- 991005545155007891
- Copyright
- Blackwell Publishing Ltd.
- Murdoch Affiliation
- Centre for Haemophilia and Thrombosis Research
- Language
- English
- Resource Type
- Journal article
- Note
- Correspondence
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.103 Blood Disorders
- 1.103.1225 Immune Thrombocytopenia
- Web Of Science research areas
- Hematology
- ESI research areas
- Clinical Medicine