Retrospective analysis of Cryptosporidium species in Western Australian human populations (2015-2018), and emergence of the C. hominis IfA12G1R5 subtype

K. Braima; A. Zahedi; C. Oskam; S. Reid; N. Pingault; L. Xiao; U. Ryan

doi:10.1016/j.meegid.2019.05.018

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Retrospective analysis of Cryptosporidium species in Western Australian human populations (2015-2018), and emergence of the C. hominis IfA12G1R5 subtype

Journal article

Peer reviewed

Retrospective analysis of Cryptosporidium species in Western Australian human populations (2015-2018), and emergence of the C. hominis IfA12G1R5 subtype

K. Braima, A. Zahedi, C. Oskam, S. Reid, N. Pingault, L. Xiao and U. Ryan

Infection, Genetics and Evolution, Vol.73, pp.306-313

2019

DOI: https://doi.org/10.1016/j.meegid.2019.05.018

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Abstract

Cryptosporidium species are a major cause of diarrhoea worldwide. In the present study, a retrospective analysis of 109 microscopically Cryptosporidium-positive faecal specimens from Western Australian patients, collected between 2015 and 2018 was conducted. Sequence analysis of the 18S rRNA and the 60 kDa glycoprotein (gp60) gene loci identified four Cryptosporidium species: C. hominis (86.2%, 94/109), C. parvum (11.0%, 12/109), C. meleagridis (1.8%, 2/109) and C. viatorum (0.9%, 1/109). Subtyping at the gp60 locus identified a total of 11 subtypes including the emergence of the previously rare C. hominis IfA12G1R5 subtype in 2017 as the dominant subtype (46.7%, 21/45). This subtype has also recently emerged as the dominant subtype in the United States but the reasons for its emergence are unknown. This is also the first report of C. viatorum in humans in Australia and a novel subtype (XVaA3g) was identified in the one positive patient.

Details

Title: Retrospective analysis of Cryptosporidium species in Western Australian human populations (2015-2018), and emergence of the C. hominis IfA12G1R5 subtype
Authors/Creators: K. Braima (Author/Creator) - Murdoch University
A. Zahedi (Author/Creator) - Murdoch University
C. Oskam (Author/Creator) - Murdoch University
S. Reid (Author/Creator) - The University of Queensland
N. Pingault (Author/Creator) - Government of Western Australia Department of Health
L. Xiao (Author/Creator) - South China Agricultural University
U. Ryan (Author/Creator) - Murdoch University
Publication Details: Infection, Genetics and Evolution, Vol.73, pp.306-313
Publisher: Elsevier BV
Identifiers: 991005544446107891
Copyright: © 2019 Elsevier B.V.
Murdoch Affiliation: College of Science, Health, Engineering and Education; Vector and Waterborne Pathogens Research Group
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.246 Diarrheal Diseases; 1.246.985 Cryptosporidium
Web Of Science research areas: Infectious Diseases
ESI research areas: Molecular Biology & Genetics