Retrospective serology study of respiratory virus infections in captive great apes

H. Buitendijk; Z. Fagrouch; H. Niphuis; W.M. Bogers; K.S. Warren; E.J. Verschoor

doi:10.3390/v6031442

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Retrospective serology study of respiratory virus infections in captive great apes

Journal article

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Peer reviewed

Retrospective serology study of respiratory virus infections in captive great apes

H. Buitendijk, Z. Fagrouch, H. Niphuis, W.M. Bogers, K.S. Warren and E.J. Verschoor

Viruses, Vol.6(3), pp.1442-1453

2014

DOI: https://doi.org/10.3390/v6031442

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Abstract

Great apes are extremely sensitive to infections with human respiratory viruses. In this study, we retrospectively analyzed sera from captive chimpanzees, gorillas and orang-utans. More than 1000 sera (403 chimpanzee, 77 gorilla, and 535 orang-utan sera) were analyzed for antibodies to the human respiratory viruses RSV (respiratory syncytial virus, hMPV (human metapneumovirus), H1N1 and H3N2 influenza A viruses, and influenza B virus. In all ape species high seroprevalences were found for RSV, hMPV, and influenza B virus. A high percentage of captive chimpanzees also showed evidence of influenza A H1N1 infections, and had low levels of H3N2 antibodies, while in sera from gorillas and orang-utans antibody levels to influenza A and B viruses were much lower or practically absent. Transmission of respiratory viruses was examined in longitudinal sera of young chimpanzees, and in chimpanzee sera taken during health checks. In young animals isolated cases of influenza infections were monitored, but evidence was found for single introductions followed by a rapid dissemination of RSV and hMPV within the group. Implementation of strict guidelines for handling and housing of nonhuman primates was shown to be an efficient method to reduce the introduction of respiratory infections in colonies of captive animals. RSV seroprevalence rates of chimpanzees remained high, probably due to circulating virus in the chimpanzee colony.

Details

Title: Retrospective serology study of respiratory virus infections in captive great apes
Authors/Creators: H. Buitendijk (Author/Creator) - Biomedical Primate Research Centre
Z. Fagrouch (Author/Creator) - Biomedical Primate Research Centre
H. Niphuis (Author/Creator) - Biomedical Primate Research Centre
W.M. Bogers (Author/Creator)
K.S. Warren (Author/Creator) - Murdoch University
E.J. Verschoor (Author/Creator) - Biomedical Primate Research Centre
Publication Details: Viruses, Vol.6(3), pp.1442-1453
Publisher: MDPI
Identifiers: 991005541047107891
Murdoch Affiliation: School of Veterinary and Life Sciences
Language: English
Resource Type: Journal article

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Collaboration types: International collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.35 Zoology & Animal Ecology; 3.35.693 Primate Behavior
Web Of Science research areas: Virology
ESI research areas: Microbiology