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Published (Version of Record)CC BY V4.0, Open Access
Journal article
Retrotransposons in the development and progression of amyotrophic lateral sclerosis
Journal of Neurology, Neurosurgery & Psychiatry, Vol.90(3), pp.284-293
2019
Abstract
Endogenous retrotransposon sequences constitute approximately 42% of the human genome, and mobilisation of retrotransposons has resulted in rearrangements, duplications, deletions, novel transcripts and the introduction of new regulatory domains throughout the human genome. Both germline and somatic de novo retrotransposition events have been involved in a range of human diseases, and there is emerging evidence for the modulation of retrotransposon activity during the development of specific diseases. Particularly, there is unequivocal consensus that endogenous retrotransposition can occur in neuronal lineages. This review addresses our current knowledge of the different mechanisms through which retrotransposons might influence the development of and predisposition to amyotrophic lateral sclerosis.
Details
- Title
- Retrotransposons in the development and progression of amyotrophic lateral sclerosis
- Authors/Creators
- A.L. Savage (Author/Creator)G.G. Schumann (Author/Creator)G. Breen (Author/Creator)V.J. Bubb (Author/Creator)A. Al-Chalabi (Author/Creator)J.P. Quinn (Author/Creator)
- Publication Details
- Journal of Neurology, Neurosurgery & Psychiatry, Vol.90(3), pp.284-293
- Publisher
- BMJ Publishing Group
- Identifiers
- 991005545390607891
- Copyright
- © Author(s) (or their employer(s)) 2019
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.54 Molecular & Cell Biology - Genetics
- 1.54.1122 Transposable Elements
- Web Of Science research areas
- Clinical Neurology
- Psychiatry
- Surgery
- ESI research areas
- Clinical Medicine