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Journal article
Right dorsal colitis in horses: A multicenter retrospective study of 35 cases
Journal of veterinary internal medicine, Vol.37(6), pp.2535-2543
2023
Abstract
Background
Right dorsal colitis (RDC) is a nonsteroidal anti-inflammatory drug (NSAID) induced, protein losing enteropathy in horses associated with a high case fatality rate.
Objectives
To describe signalment, NSAID usage, clinical presentations, clinical pathology, ultrasonographic findings, treatments, outcomes, and factors associated with survival in horses diagnosed with RDC.
Animals
Thirty-five horses from 7 Australian equine hospitals diagnosed with RDC.
Methods
Retrospective case series. Clinical records of cases were accepted if definitively or presumptively diagnosed by an internist with RDC and had ≥3 of: hypoproteinemia or hypoalbuminemia; diarrhea with negative test results for infectious diseases; colic for which other diseases were excluded or right dorsal colon thickening on ultrasound. Descriptive data analysis was performed for categorical and continuous variables. Univariate binominal logistic regressions were used to assess factors associated with survival.
Results
An overdose of NSAIDs occurred in 84% (21/25) cases where dose was known. Common clinical presentations included diarrhea (69%; 22/32), colic (61%; 20/33), and tachycardia (53%, 17/32). Common clinicopathological findings included hypoalbuminemia (83%; 26/31), hypocalcaemia (79%, 23/29), and hyperlactatemia (77%, 14/18). The right dorsal colon wall appeared subjectively thickened in 77% (24/31) cases using ultrasonography. Case fatality rate was 43% (15/35). Odds of survival significantly decreased with increasing heart rate (odds 0.84, 95% CI = 0.71-0.92, P = .01), packed cell volume (odds 0.91, 95% CI 0.82-0.98, P = .05) and abnormal appearance of mucous membranes (odds 0.05, 95% CI 0.005-0.28, P = .001) on hospital presentation.
Conclusions and Clinical Importance
An overdose of NSAIDs is common in horses diagnosed with RDC. Serum albumin concentrations should be monitored in horses receiving a prolonged course of NSAIDs. Overall prognosis for RDC remains fair.
Details
- Title
- Right dorsal colitis in horses: A multicenter retrospective study of 35 cases
- Authors/Creators
- Jordan Flood - The University of QueenslandDavid Byrne - School of Veterinary Medicine Murdoch University Perth Western Australia AustraliaJennifer Bauquier - The University of MelbourneGustavo Ferlini Agne - The University of AdelaideJessica C. Wise - Charles Sturt UniversityCarlos E. Medina-Torres - School of Veterinary Science University of Queensland Gatton Queensland AustraliaKelly Wood - The University of QueenslandOlivia Sullivan - The University of MelbourneAllison J. Stewart - The University of Queensland
- Publication Details
- Journal of veterinary internal medicine, Vol.37(6), pp.2535-2543
- Publisher
- Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
- Identifiers
- 991005609153107891
- Copyright
- © 2023 The Authors.
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
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- Citation topics
- 1 Clinical & Life Sciences
- 1.181 Molecular Toxicology
- 1.181.399 NSAIDs and COX Inhibitors
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science