Journal article
Rimonabant attenuates amphetamine sensitisation in a CCK2 receptor-dependent manner
Behavioural Brain Research, Vol.226(1), pp.335-339
2012
Abstract
In this behavioural and pharmacological study in male CCK2 receptor-deficient mice (CCK2−/−), we evaluated the role of the interaction of endocannabinoids (eCBs) and cholecystokinin (CCK) on the regulation of anxiety-related and motor behaviours. Repeated treatment with amphetamine (2 mg/kg daily for four days) induced slightly weaker motor sensitisation in CCK2−/− mice compared to their wild-type (CCK2+/+) littermates. Co-administration of rimonabant (1 mg/kg) with amphetamine antagonised the development of motor sensitisation in CCK2+/+ mice. However, we did not find a similar effect of rimonabant in CCK2−/− mice. We did not find any differences between the behaviour of CCK2+/+ and CCK2−/− mice in models designed to assess emotional behaviours (dark/light exploration, marble burying and conditioned place aversion). This study supports the hypothesis that eCBs play a role in the development of amphetamine-induced sensitisation. Moreover, we have demonstrated that intact CCK2 receptors are necessary for the development of eCB-mediated sensitisation to amphetamine.
Details
- Title
- Rimonabant attenuates amphetamine sensitisation in a CCK2 receptor-dependent manner
- Authors/Creators
- K. Rünkorg (Author/Creator) - University of TartuL. Orav (Author/Creator) - University of TartuS. Kõks (Author/Creator) - University of TartuT. Matsui (Author/Creator) - University of TartuV. Volke (Author/Creator) - University of TartuE. Vasar (Author/Creator) - University of Tartu
- Publication Details
- Behavioural Brain Research, Vol.226(1), pp.335-339
- Publisher
- Elsevier B.V.
- Identifiers
- 991005544594107891
- Copyright
- © 2011 Elsevier B.V.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.195 Neuroendocrine & Intestinal Disorders
- 1.195.1096 Gastrin/CCK Functions
- Web Of Science research areas
- Behavioral Sciences
- Neurosciences
- ESI research areas
- Neuroscience & Behavior