Journal article
Role of CCK in anti-exploratory action of paroxetine, 5-HT reuptake inhibitor
The International Journal of Neuropsychopharmacology, Vol.2(1), pp.9-16
1999
Abstract
The administration of paroxetine (0.5–8 mg/kg), a selective 5-HT reuptake inhibitor, induced a dose-dependent reduction of exploratory activity of rats in the motility test. In the elevated plus-maze paroxetine was less effective, only 8 mg/kg of paroxetine decreased the exploratory behaviour of rats. The doses of paroxetine (2–8 mg/kg) reducing the exploratory activity in the motility test increased the density of CCK receptors in the frontal cortex, but not in the hippocampus. The treatment of rats with the CCKB receptor antagonist LY288,513 (0.01–1 mg/kg) did not change the exploratory activity. However, the reduction of exploratory activity induced by the low dose of paroxetine (2 mg/kg), but not by the higher dose (8 mg/kg), was dose-dependently reversed by the administration of LY288,513. Moreover, LY288,513 did not affect the anti-exploratory action of paroxetine (8 mg/kg) in the elevated plus-maze. Diazepam at doses (0.5–1.0 mg/kg) not suppressing the locomotor activity did not change the anti-exploratory action of paroxetine in the motility test. It is likely that the anti-exploratory action of a low dose of paroxetine (2 mg/kg) is not related to the increase in anxiety, but rather to the reduction of exploratory drive. Evidence exists that this effect of paroxetine is mediated via the activation of CCK-ergic transmission.
Details
- Title
- Role of CCK in anti-exploratory action of paroxetine, 5-HT reuptake inhibitor
- Authors/Creators
- S. Kõks (Author/Creator) - University of TartuM. Bourin (Author/Creator) - Nantes UniversitéV. Võikar (Author/Creator) - University of TartuA. Soosaar (Author/Creator) - University of TartuE. Vasar (Author/Creator) - University of Tartu
- Publication Details
- The International Journal of Neuropsychopharmacology, Vol.2(1), pp.9-16
- Publisher
- Collegium Internationale Neuropsychopharmacologicum
- Identifiers
- 991005545387007891
- Copyright
- © 1999 Collegium Internationale Neuro-Psychopharmacologicum
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.195 Neuroendocrine & Intestinal Disorders
- 1.195.1096 Gastrin/CCK Functions
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- Pharmacology & Pharmacy
- Psychiatry
- ESI research areas
- Psychiatry/Psychology