Journal article
Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia
Proceedings of the National Academy of Sciences, Vol.102(30), pp.10682-10687
2005
Abstract
Wild waterfowl, including ducks, are natural hosts of influenza A viruses. These viruses rarely caused disease in ducks until 2002, when some H5N1 strains became highly pathogenic. Here we show that these H5N1 viruses are reverting to nonpathogenicity in ducks. Ducks experimentally infected with viruses isolated between 2003 and 2004 shed virus for an extended time (up to 17 days), during which variant viruses with low pathogenicity were selected. These results suggest that the duck has become the "Trojan horse" of Asian H5N1 influenza viruses. The ducks that are unaffected by infection with these viruses continue to circulate these viruses, presenting a pandemic threat
Details
- Title
- Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia
- Authors/Creators
- D.J. Hulse-Post (Author/Creator) - St. Jude Children's Research HospitalK.M. Sturm-Ramirez (Author/Creator)J. Humberd (Author/Creator)P. Seiler (Author/Creator)E.A. Govorkova (Author/Creator)S. Krauss (Author/Creator)C. Scholtissek (Author/Creator)P. Puthavathana (Author/Creator)C. Buranathai (Author/Creator)T.D. Nguyen (Author/Creator)H.T. Long (Author/Creator)T.S.P. Naipospos (Author/Creator)H. Chen (Author/Creator)T.M. Ellis (Author/Creator)Y. Guan (Author/Creator)J.S.M. Peiris (Author/Creator)R.G. Webster (Author/Creator)
- Publication Details
- Proceedings of the National Academy of Sciences, Vol.102(30), pp.10682-10687
- Publisher
- National Academy of Sciences
- Identifiers
- 991005540024507891
- Copyright
- © 2005 by The National Academy of Sciences of the USA.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.104 Virology - General
- 1.104.126 Influenza
- Web Of Science research areas
- Virology
- ESI research areas
- Microbiology