Role of neuregulin-1β in dexamethasone-enhanced surfactant synthesis in fetal type II cells

G. King; G.L. Maker; D. Berryman; R.D. Trengove; M.H. Cake

doi:10.1016/j.febslet.2014.01.057

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Role of neuregulin-1β in dexamethasone-enhanced surfactant synthesis in fetal type II cells

Journal article

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Peer reviewed

Role of neuregulin-1β in dexamethasone-enhanced surfactant synthesis in fetal type II cells

G. King, G.L. Maker, D. Berryman, R.D. Trengove and M.H. Cake

FEBS Letters, Vol.588(6), pp.975-980

2014

DOI: https://doi.org/10.1016/j.febslet.2014.01.057

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Abstract

It is well established that glucocorticoids elevate the production of fibroblast-pneumocyte factor (FPF), which induces type II cells to synthesize surfactant phospholipids. FPF, however, has not been identified and it is not clear whether it is a single factor or a complex mixture of factors. In this study it has been shown that, when lung fibroblasts are exposed to dexamethasone, the concentration of neuregulin-1β (NRG1β) in conditioned medium is elevated 2-fold (P < 0.05), even though NRG1β gene expression is unaffected. This, together with the finding that exposure of type II cells to NRG1β directly stimulates by 3-fold the rate of phospholipid synthesis (P < 0.05), suggests that NRG1β is a component of FPF that promotes lung development.

Details

Title: Role of neuregulin-1β in dexamethasone-enhanced surfactant synthesis in fetal type II cells
Authors/Creators: G. King (Author/Creator) - Murdoch University
G.L. Maker (Author/Creator) - Murdoch University
D. Berryman (Author/Creator) - Murdoch University
R.D. Trengove (Author/Creator) - Murdoch University
M.H. Cake (Author/Creator) - Murdoch University
Publication Details: FEBS Letters, Vol.588(6), pp.975-980
Publisher: Elsevier
Identifiers: 991005540162207891
Copyright: © 2014 Federation of European Biochemical Societies
Murdoch Affiliation: School of Veterinary and Life Sciences
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.154 Assisted Ventilation; 1.154.1057 Pulmonary Surfactant
Web Of Science research areas: Biochemistry & Molecular Biology; Biophysics; Cell Biology
ESI research areas: Biology & Biochemistry