Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway

J. Chen; J. Wang; Y. Deng; T. Wang; T. Miao; C. Li; X. Cai; Y. Liu; J. Henri; L. Chen

doi:10.1155/2020/8890950

Back

Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway

Journal article

Open access

Peer reviewed

Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway

J. Chen, J. Wang, Y. Deng, T. Wang, T. Miao, C. Li, X. Cai, Y. Liu, J. Henri and L. Chen

Bioinorganic Chemistry and Applications, Vol.2020, pp.1-16

2020

DOI: https://doi.org/10.1155/2020/8890950

Files and links (2)

pdf

A549 cells.pdfDownload View

Published (Version of Record) Open Access

url

Free to Read *No subscription requiredView

Abstract

Two new Ru(II) complexes containing O, O-chelated ligands, Ru(dip)2(SA) (Ru-1) and Ru(dmp)2(SA) (Ru-2) (dip = 4,7-diphenyl-1,10-phenanthroline; dmp = 2,9-dimethyl-1,10-phenanthroline; SA = salicylate) were synthesized to evaluate their cytotoxicity in vitro. These complexes were found to exhibit moderate antitumor activity to different types of human cancers, including A549 (human lung carcinoma), MCF-7 (breast cancer), HeLa (human cervical cancer), and HepG2 (human hepatocellular carcinoma) cell lines, but displayed low toxicity to human normal cell lines BEAS-2B (immortalized human bronchial epithelial cells) when compared with that of cisplatin. Further studies revealed that these complexes could induce apoptosis in A549 cells, including activating caspase family proteins and poly (ADP-ribose) polymerase (PARP), reducing Bcl-2/Bax and Bcl-xl/Bad ratio, enhancing cellular reactive oxygen species (ROS) accumulation, triggering DNA damage, decreasing mitochondrial membrane potential (MMP), and leading cytochrome c release from mitochondria. Notably, complex Ru-1 showed low toxicity to developing zebrafish embryos. The obtained results suggest that these new synthetic complexes have the potential to be developed as low-toxicity agents for lung cancer treatment.

Details

Title: Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway
Authors/Creators: J. Chen (Author/Creator) - Guangdong Medical College
J. Wang (Author/Creator) - Guangdong Medical College
Y. Deng (Author/Creator) - Guangdong Medical College
T. Wang (Author/Creator) - Murdoch University
T. Miao (Author/Creator) - Huaibei Normal University
C. Li (Author/Creator) - Marine Biomedical Research Institute of Qingdao
X. Cai (Author/Creator) - Guangdong Medical College
Y. Liu (Author/Creator) - Guangdong Medical College
J. Henri (Author/Creator) - Deakin University
L. Chen (Author/Creator) - Guangdong Medical College
Publication Details: Bioinorganic Chemistry and Applications, Vol.2020, pp.1-16
Publisher: Hindawi Publishing
Identifiers: 991005544805407891
Copyright: © 2020 Jincan Chen et al.
Murdoch Affiliation: Centre for Molecular Medicine and Innovative Therapeutics
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

65 File views/ downloads

31 Record Views

16 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 2 Chemistry; 2.22 Inorganic & Nuclear Chemistry; 2.22.798 Metal Anticancer Complexes
Web Of Science research areas: Biochemistry & Molecular Biology; Chemistry, Inorganic & Nuclear; Chemistry, Organic
ESI research areas: Chemistry