S100/CD34-Positive Spindle Cell Mesenchymal Neoplasm Harboring KIAA1549-BRAF Fusion

D.J.W. Paton; D. Wong; B. Amanuel; K. Cheah; N.M. Ardakani

doi:10.1097/DAD.0000000000001796

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S100/CD34-Positive Spindle Cell Mesenchymal Neoplasm Harboring KIAA1549-BRAF Fusion

Journal article

Peer reviewed

S100/CD34-Positive Spindle Cell Mesenchymal Neoplasm Harboring KIAA1549-BRAF Fusion

D.J.W. Paton, D. Wong, B. Amanuel, K. Cheah and N.M. Ardakani

The American Journal of Dermatopathology, Vol.43(3), pp.217-220

2021

DOI: https://doi.org/10.1097/DAD.0000000000001796

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Abstract

Mesenchymal neoplasms with oncogenic kinase activity due to genomic alterations in receptor tyrosine kinase genes are a morphologically heterogeneous group with a variable biologic potential. A subset of these neoplasms are characterized by immunophenotypic property of dual S100 protein/CD34 expression, histopathological resemblance to lipofibromatosis or peripheral nerve sheath tumors, and often alterations in neurotrophic tropomyosin-related kinase genes. In this article, we present a case of an S100 protein/CD34-positive spindle cell neoplasm harboring a rare BRAF gene rearrangement (KIAA1549-BRAF fusion) and discuss the clinical, histopathological, and molecular variations associated with such neoplasms.

Details

Title: S100/CD34-Positive Spindle Cell Mesenchymal Neoplasm Harboring KIAA1549-BRAF Fusion
Authors/Creators: D.J.W. Paton (Author/Creator) - Curtin University
D. Wong (Author/Creator) - The University of Western Australia
B. Amanuel (Author/Creator) - Edith Cowan University
K. Cheah (Author/Creator) - South Australia Pathology
N.M. Ardakani (Author/Creator) - Murdoch University
Publication Details: The American Journal of Dermatopathology, Vol.43(3), pp.217-220
Publisher: Wolters Kluwer
Identifiers: 991005540660307891
Copyright: © 2020 Wolters Kluwer Health, Inc.
Murdoch Affiliation: School of Veterinary and Life Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.199 Lung Cancer; 1.199.581 NSCLC Treatments
Web Of Science research areas: Dermatology
ESI research areas: Clinical Medicine