Journal article
SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron
Cell, Vol.185(5), pp.P847-859
2022
Abstract
We address whether T cell responses induced by different vaccine platforms (mRNA-1273, BNT162b2, Ad26.COV2.S, NVX-CoV2373) cross-recognize early SARS-CoV-2 variants. T cell responses to early variants were preserved across vaccine platforms. By contrast, significant overall decreases were observed for memory B cells and neutralizing antibodies. In subjects ∼6 months post-vaccination, 90% (CD4+) and 87% (CD8+) of memory T cell responses were preserved against variants on average by AIM assay, and 84% (CD4+) and 85% (CD8+) preserved against Omicron. Omicron RBD memory B cell recognition was substantially reduced to 42% compared to other variants. T cell epitope repertoire analysis revealed a median of 11 and 10 spike epitopes recognized by CD4+ and CD8+ T cells, with average preservation > 80% for Omicron. Functional preservation of the majority of T cell responses may play an important role as second-level defenses against diverse variants.
Details
- Title
- SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron
- Authors/Creators
- A. Tarke (Author/Creator)C.H. Coelho (Author/Creator)Z. Zhang (Author/Creator)J.M. Dan (Author/Creator)E.D. Yu (Author/Creator)N. Methot (Author/Creator)N.I. Bloom (Author/Creator)B. Goodwin (Author/Creator)E. Phillips (Author/Creator)S. Mallal (Author/Creator)J. Sidney (Author/Creator)G. Filaci (Author/Creator)D. Weiskopf (Author/Creator)R. da Silva Antunes (Author/Creator)S. Crotty (Author/Creator)A. Grifoni (Author/Creator)A. Sette (Author/Creator)
- Publication Details
- Cell, Vol.185(5), pp.P847-859
- Publisher
- Elsevier
- Identifiers
- 991005542786407891
- Copyright
- © 2022 Elsevier Inc.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.104 Virology - General
- 1.104.1353 Coronavirus Research
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- ESI research areas
- Molecular Biology & Genetics