SNCA Gene, but not MAPT, influences onset age of Parkinson’s Disease in Chinese and Australians

Y. Huang; G. Wang; D. Rowe; Y. Wang; J.B.J. Kwok; Q. Xiao; F. Mastaglia; J. Liu; S-D Chen; G. Halliday

doi:10.1155/2015/135674

Back

SNCA Gene, but not MAPT, influences onset age of Parkinson’s Disease in Chinese and Australians

Journal article

Open access

Peer reviewed

SNCA Gene, but not MAPT, influences onset age of Parkinson’s Disease in Chinese and Australians

Y. Huang, G. Wang, D. Rowe, Y. Wang, J.B.J. Kwok, Q. Xiao, F. Mastaglia, J. Liu, S-D Chen and G. Halliday

BioMed Research International, Vol.2015, pp.1-6

2015

DOI: https://doi.org/10.1155/2015/135674

Files and links (2)

pdf

SNCA_gene.pdfDownload View

Published (Version of Record) Open Access

url

Free to Read *No subscription requiredView

Abstract

Background. α-Synuclein (SNCA) and microtubule-associated protein tau (MAPT) are the two major genes independently, but not jointly, associated with susceptibility for Parkinson’s disease (PD). The SNCA gene has recently been identified as a major modifier of age of PD onset. Whether MAPT gene synergistically influences age of onset of PD is unknown. Objective. To investigate independent and joint effects of MAPT and SNCA on PD onset age. Methods. 412 patients with PD were recruited from the Australian PD Research Network (123) and the Neurology Department, Ruijin Hospital Affiliated to Shanghai Jiaotong University, China (289). MAPT (rs17650901) tagging H1/H2 haplotype and SNCA (Rep1) were genotyped in the Australian cohort, and MAPT (rs242557, rs3744456) and SNCA (rs11931074, rs894278) were genotyped in the Chinese cohort. SPSS regression analysis was used to test genetic effects on age at onset of PD in each cohort. Results. SNCA polymorphisms associated with the onset age of PD in both populations. MAPT polymorphisms did not enhance such association in either entire cohort. Conclusion. This study suggests that, in both ethnic groups, SNCA gene variants influence the age at onset of PD and α-synuclein plays a key role in the disease course of PD.

Details

Title: SNCA Gene, but not MAPT, influences onset age of Parkinson’s Disease in Chinese and Australians
Authors/Creators: Y. Huang (Author/Creator) - Neuroscience Research Australia
G. Wang (Author/Creator) - Ruijin Hospital
D. Rowe (Author/Creator) - Australian School of Advanced Medicine
Y. Wang (Author/Creator) - Ruijin Hospital
J.B.J. Kwok (Author/Creator) - Neuroscience Research Australia
Q. Xiao (Author/Creator) - Ruijin Hospital
F. Mastaglia (Author/Creator) - Murdoch University
J. Liu (Author/Creator) - Ruijin Hospital
S-D Chen (Author/Creator) - Ruijin Hospital
G. Halliday (Author/Creator) - Neuroscience Research Australia
Publication Details: BioMed Research International, Vol.2015, pp.1-6
Publisher: Hindawi Publishing Corporation
Identifiers: 991005542932807891
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

203 File views/ downloads

125 Record Views

14 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.67 Parkinson's Disease
Web Of Science research areas: Biotechnology & Applied Microbiology; Medicine, Research & Experimental
ESI research areas: Biology & Biochemistry