Journal article
SPON1 Is associated with Amyloid-β and APOE ε4-Related cognitive decline in cognitively normal adults
Journal of Alzheimer's Disease Reports, Vol.5(1), pp.111-120
2021
Abstract
Background:
Genetic variation in Spondin-1, specifically rs11023139, has been associated with reduced rates of cognitive decline in individuals with Alzheimer’s disease.
Objective:
The aim of this study was to assess whether the association was present in cognitively normal older adults.
Methods:
Longitudinal cognitive decline was investigated using linear mixed modelling in a cohort of 590 cognitively normal older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Study.
Results:
No independent effect of Spondin-1 rs11023139 on cognitive decline was observed. However, significant associations were observed for the interaction between Apolipoprotein E (APOE) ɛ4 and rs11023139 in individuals with high amyloid-β burden. APOE ɛ4/rs11023139-A carriers declined significantly faster than APOE ɛ4/rs11023139-G_G carriers in measures of global cognition (p = 0.011) and verbal episodic memory (p = 0.020).
Conclusion:
These results suggest that carriage of the Spondin-1 rs11023139-A allele significantly contributes to a worsening of cognitive performance in APOE ɛ4 cognitively normal older adults with a high neocortical amyloid-β burden.
Details
- Title
- SPON1 Is associated with Amyloid-β and APOE ε4-Related cognitive decline in cognitively normal adults
- Authors/Creators
- S. Fernandez (Author/Creator)S.C. Burnham (Author/Creator)L. Milicic (Author/Creator)G. Savage (Author/Creator)P. Maruff (Author/Creator)M. Peretti (Author/Creator)H.R. Sohrabi (Author/Creator)Y.Y. Lim (Author/Creator)M. Weinborn (Author/Creator)D. Ames (Author/Creator)C.L. Masters (Author/Creator)R.N. Martins (Author/Creator)S. Rainey-Smith (Author/Creator)C.C. Rowe (Author/Creator)O. Salvado (Author/Creator)D. Groth (Author/Creator)G. Verdile (Author/Creator)V.L. Villemagne (Author/Creator)T. Porter (Author/Creator)S.M. Laws (Author/Creator)
- Publication Details
- Journal of Alzheimer's Disease Reports, Vol.5(1), pp.111-120
- Publisher
- IOS Press
- Identifiers
- 991005545134007891
- Copyright
- © 2021 The Authors.
- Murdoch Affiliation
- Centre for Healthy Ageing
- Language
- English
- Resource Type
- Journal article
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