Journal article
Safety, efficacy and effectiveness of delabeling in patients with multiple drug allergy labels
The Journal of Allergy and Clinical Immunology: In Practice, Vol.9(2), pp.922-928
2020
Abstract
Background
Patients with multiple drug allergy labels (MDAL) present a challenging barrier to patient care.
Objective
To assess the efficacy, safety and effectiveness of removing MDAL in a single clinic visit.
Methods
Retrospective chart review was performed from October 1, 2014 to October 31, 2018 on MDAL patients who had electronic health record (EHR) allergy label to two or more drug and who were delabeled to ≥1 drug.. Our primary outcome was the number of allergy labels tested and removed, at a single or multiple visits. Post-visit surveys were administered to patients, their pharmacies and primary care physicians (PCP) for patients delabeled following an EHR transition from November 2, 2017 to October 31st 2018 (n=184).
Results
Among 536 patients meeting inclusion criteria, 916/943 (97.1%) of tested allergy labels were removed from the EHR . Most patients 461/536 (86.0%) were tested, challenged and delabeled in a single visit, to ≥ 1 drug, although 134/536 (25%) still had evidence of > 1 label at one year. In surveys, 90/171 (52.6%) of responding pharmacies and 122/168 (72.6%) of PCPs contacted had removed drug labels from the EHR as a result of the recommendations from the patient’s drug allergy evaluation. Overall, 91/142 (64.1%) of MDAL patient survey respondents were willing to take the drugs to which they had been delabeled.
Conclusions
MDAL patients can be safely delabeled to multiple drugs in one visit, however effectiveness barriers were identified. Reinforcement of drug allergy label removal information to patients, pharmacies and primary care providers presents a targeted area for improvement.
Details
- Title
- Safety, efficacy and effectiveness of delabeling in patients with multiple drug allergy labels
- Authors/Creators
- C. Vethody (Author/Creator)R. Yu (Author/Creator)J.M. Keck (Author/Creator)M.K. Onasch (Author/Creator)C.A. Stone (Author/Creator)E.J. Phillips (Author/Creator)
- Publication Details
- The Journal of Allergy and Clinical Immunology: In Practice, Vol.9(2), pp.922-928
- Publisher
- Elsevier
- Identifiers
- 991005540732407891
- Copyright
- © 2020 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
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- Citation topics
- 1 Clinical & Life Sciences
- 1.265 Dermatology - Skin Allergies
- 1.265.1140 Drug Hypersensitivity
- Web Of Science research areas
- Allergy
- Immunology
- ESI research areas
- Clinical Medicine