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Journal article
Safety of exercise training in multiple sclerosis: An updated systematic review and meta-analysis
Multiple sclerosis, Vol.29(13), pp.1604-1631
2023
Appears in Open Access via Read & Publish Agreements
Abstract
Background: A review of the safety profile of exercise training in multiple sclerosis (MS) has not been conducted since 2013.
Objective: We undertook a systematic review and meta-analysis of randomised controlled trials (RCTs) of exercise training published since 2013 and quantified estimated population risks of clinical relapse, adverse events (AE) and serious adverse event (SAE).
Methods: Articles reporting safety outcomes from comparisons of exercise training with non-exercise among persons with MS were identified. The risk of bias was established from study’s internal validity assessed using Physiotherapy Evidence Database (PEDro). Rates and estimated mean population relative risks (RRs; 95% confidence interval (CI)) of safety outcomes were calculated, and random-effects meta-analysis estimated the mean RR.
Results: Forty-six interventions from 40 RCTs ( N = 1780) yielded 46, 40 and 39 effects for relapse, AE, adverse effects and SAE, respectively. The mean population RRs ((95% CI), p-value) for relapse, AE and SAE were 0.95 ((0.61, 1.48), p = 0.82), 1.40 ((0.90, 2.19), p = 0.14) and 1.05 ((0.62, 1.80), p = 0.85), respectively. No significant heterogeneity is observed for any outcome.
Conclusion: In studies that reported safety outcomes, there was no higher risk of relapse, AE, adverse effects or SAE for exercise training than the comparator. Exercise training may be promoted as safe and beneficial to persons with MS.
Details
- Title
- Safety of exercise training in multiple sclerosis: An updated systematic review and meta-analysis
- Authors/Creators
- Yvonne C Learmonth - Murdoch University, Centre for Molecular Medicine and Innovative TherapeuticsMatthew P Herring - University of LimerickDaniel I Russell - Discipline of Psychology, Murdoch University, Murdoch, WA, AustraliaLara A Pilutti - University of OttawaSandra Day - Discipline of Psychology, Murdoch University, Murdoch, WA, AustraliaClaudia H Marck - The University of MelbourneBryan Chan - Murdoch UniversityAlexandra P Metse - University of the Sunshine CoastRobert W Motl - University of Illinois Chicago
- Publication Details
- Multiple sclerosis, Vol.29(13), pp.1604-1631
- Publisher
- SAGE Publications
- Identifiers
- 991005612268907891
- Copyright
- © 2023 The Author(s).
- Murdoch Affiliation
- School of Psychology
- Language
- English
- Resource Type
- Journal article
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