Salmonella enterica isolated from infections in Australian livestock remain susceptible to critical antimicrobials

S. Abraham; M.D. Groves; D.J. Trott; T.A. Chapman; B. Turner; M. Hornitzky; D. Jordan

doi:10.1016/j.ijantimicag.2013.10.014

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Salmonella enterica isolated from infections in Australian livestock remain susceptible to critical antimicrobials

Journal article

Peer reviewed

Salmonella enterica isolated from infections in Australian livestock remain susceptible to critical antimicrobials

S. Abraham, M.D. Groves, D.J. Trott, T.A. Chapman, B. Turner, M. Hornitzky and D. Jordan

International Journal of Antimicrobial Agents, Vol.43(2), pp.126-130

2014

DOI: https://doi.org/10.1016/j.ijantimicag.2013.10.014

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Abstract

Salmonella enterica is a zoonotic pathogen causing a variety of diseases in humans and animals. Many countries are reporting an increase in the prevalence of multidrug-resistant (MDR) S. enterica in food animals. The aim of this study was to determine whether S. enterica isolated from livestock in New South Wales, Australia, have similar resistance traits to those reported internationally. Salmonella enterica (n = 165) from clinical infections in food animals between 2007 and 2011 were serotyped and tested for susceptibility to 18 antimicrobials. Also, 22 antimicrobial resistance genes (ARGs), 3 integrons and 18 plasmid replicon types were screened for using PCR. Most isolates (66.1%) remained susceptible to all antimicrobials; 8.5% of the isolates were resistant to four or more antimicrobials. Antimicrobials with the highest prevalence of resistance were sulfafurazole (28.5%), ampicillin (17.0%), tetracycline (15.8%) and trimethoprim (8.5%). There was no resistance to fluoroquinolones or third-generation cephalosporins. The most common ARGs were blaTEM (15.2%), sul2 (10.3%), tetB (9.1%), tetA (5.5%), aphA1 (4.8%) and dhfrV (4.8%). Class 1 integrons (7.9%) and IncFIIA (69.7%) were the most commonly detected integron and plasmid replicon types, respectively. Class 1 integrons were positively associated with MDR phenotypes and ARG carriage (P ≤ 0.001). Internationally prominent MDR serovars associated with severe disease in humans (e.g. AmpC-positive Salmonella Newport) were not detected. Overall, the comparatively favourable resistance status of S. enterica in Australian livestock represents minimal public health risk associated with MDR strains and supports a conservative approach to the registration of antimicrobial drug classes in food-producing animals.

Details

Title: Salmonella enterica isolated from infections in Australian livestock remain susceptible to critical antimicrobials
Authors/Creators: S. Abraham (Author/Creator)
M.D. Groves (Author/Creator)
D.J. Trott (Author/Creator)
T.A. Chapman (Author/Creator)
B. Turner (Author/Creator)
M. Hornitzky (Author/Creator)
D. Jordan (Author/Creator)
Publication Details: International Journal of Antimicrobial Agents, Vol.43(2), pp.126-130
Publisher: Elsevier
Identifiers: 991005542995107891
Copyright: © 2013 Published by Elsevier B.V. on behalf of International Society of Chemotherapy.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.42 Bacteriology; 1.42.376 Salmonella and Campylobacter
Web Of Science research areas: Infectious Diseases; Microbiology; Pharmacology & Pharmacy
ESI research areas: Pharmacology & Toxicology