Scaling-up engineering biology for enhanced environmental solutions

Francis Hassard; Thomas P Curtis; Gabriela C Dotro; Peter Golyshin; Tony Gutierrez; Sonia Heaven; Louise Horsfall; Bruce Jefferson; Davey L Jones; Natalio Krasnogor; Vinod Kumar; David J Lea-Smith; Kristell Le Corre Pidou; Yongqiang Liu; Tao Lyu; Ronan R McCarthy; Boyd McKew; Cindy Smith; Alexander Yakunin; Zhugen Yang; Yue Zhang; Frederic Coulon

doi:10.1021/acssynbio.4c00292

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Scaling-up engineering biology for enhanced environmental solutions

Journal article

Open access

Peer reviewed

Scaling-up engineering biology for enhanced environmental solutions

Francis Hassard, Thomas P Curtis, Gabriela C Dotro, Peter Golyshin, Tony Gutierrez, Sonia Heaven, Louise Horsfall, Bruce Jefferson, Davey L Jones, Natalio Krasnogor, …

ACS synthetic biology, Vol.13(6), pp.1586-1588

2024

DOI: https://doi.org/10.1021/acssynbio.4c00292

PMCID: PMC11197081

PMID: 38903005

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Abstract

Synthetic biology (SynBio) offers transformative solutions for addressing environmental challenges by engineering organisms capable of degrading pollutants, enhancing carbon sequestration, and valorizing waste (Figure 1). These innovations hold the potential to revolutionize bioremediation strategies, ecosystem restoration, and sustainable environmental management. (1) Advances in SynBio, including automation, precise manipulation of genetic material, (2) and design of semisynthetic organisms with enhanced capabilities, can improve the efficiency of microbes for eliminating pollutants such as hydrocarbons and plastics or extracting valuable resources from the environment. (3) Genome editing technologies, such as CRISPR-Cas9, allows the editing of genomes with unprecedented accuracy, facilitating the development of organisms with desired traits or functions. (4) Furthermore, SynBio encompasses the engineering of metabolic enzymes within organisms, leading to the design of microbial factories capable of degrading complex and persistent chemicals, and converting waste to valuable resources. (5) These advancements also facilitate the manipulation of bacterial social behaviors, offering the capacity for tunable control at the multicellular level and engineered biofilms.

Details

Title: Scaling-up engineering biology for enhanced environmental solutions
Authors/Creators: Francis Hassard
Thomas P Curtis
Gabriela C Dotro
Peter Golyshin
Tony Gutierrez
Sonia Heaven
Louise Horsfall
Bruce Jefferson
Davey L Jones
Natalio Krasnogor
Vinod Kumar
David J Lea-Smith
Kristell Le Corre Pidou
Yongqiang Liu
Tao Lyu
Ronan R McCarthy
Boyd McKew
Cindy Smith
Alexander Yakunin
Zhugen Yang
Yue Zhang
Frederic Coulon
Publication Details: ACS synthetic biology, Vol.13(6), pp.1586-1588
Publisher: American Chemical Society
Identifiers: 991005686561007891
Murdoch Affiliation: Centre for Sustainable Farming Systems
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.54 Molecular & Cell Biology - Genetics; 1.54.629 Synthetic Biology
Web Of Science research areas: Biochemical Research Methods
ESI research areas: Biology & Biochemistry